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AuthorJoshy K.S.
AuthorAugustine R.
AuthorMayeen A.
AuthorAlex S.M.
AuthorHasan, Anwarul
AuthorThomas S.
AuthorChi H.
Available date2022-05-21T10:18:29Z
Publication Date2020
Publication NameNew Journal of Chemistry
ResourceScopus
Identifierhttp://dx.doi.org/10.1039/d0nj01163k
URIhttp://hdl.handle.net/10576/31292
AbstractThe present study reports the fabrication of hybrid nanoparticles consisting of nickel ferrite (NFO) for anti cancer drug delivery. The hybrid system was formulated from poly(vinyl alcohol)/stearic acid with PEG containing nickel ferrite for zidovudine (AZT) delivery. The nickel ferrite nanoparticles were characterized by XRD and TEM analysis. The hybrid nanoparticles were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM), and their influence on biological systems was evaluated by blood compatibility and cell viability studies. The encapsulation of AZT into the hybrid nanoparticles was assessed by evaluating the drug loading, encapsulation efficiency and release studies. The advantages of incorporating magnetic nanoparticles into self-assembled hybrid nanoparticles include the ability to load large amounts of drugs along with control over drug release. In this regard, the presented nickel ferrite reinforced hybrid nanoparticles containing zidovudine is a demanding platform that can act in a pH responsive manner enabling site specific intracellular anticancer drug delivery. Its impact is therefore noteworthy, extensive, and prevalent in cancer therapy.
Languageen
PublisherRoyal Society of Chemistry
SubjectControlled drug delivery
Diseases
Dynamic light scattering
Ethylene
Ethylene glycol
Ferrite
High resolution transmission electron microscopy
Hybrid systems
Nickel
Nickel metallography
Polyvinyl alcohols
Targeted drug delivery
Anti-cancer drug delivery
Blood compatibility
Cancer therapy
Cell viability
Encapsulation efficiency
Hybrid nanoparticle
Nickel ferrite
Nickel ferrite nanoparticle
Magnetic nanoparticles
lipid nanoparticle
macrogol
nickel ferrite nanoparticle
nickel nanoparticle
polymer nanoparticle
polyvinyl alcohol
stearic acid
unclassified drug
zidovudine
antineoplastic activity
Article
biocompatibility
blood compatibility
cell viability
controlled study
cytology
drug delivery system
human
human cell
in vitro study
nanoencapsulation
nanopharmaceutics
photon correlation spectroscopy
priority journal
sustained drug release
transmission electron microscopy
X ray diffraction
TitleNiFe2O4/poly(ethylene glycol)/lipid-polymer hybrid nanoparticles for anti-cancer drug delivery
TypeArticle
Issue Number42
Volume Number44
dc.accessType Abstract Only


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