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    Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases

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    pharmaceutics-17-00893-v2.pdf (4.440Mb)
    Date
    2025
    Author
    Mahmoud, Doaa Elsayed
    Hosseini, Seyedeh Hanieh
    Rathore, Hassaan Anwer
    Alkilany, Alaaldin M.
    Heise, Andreas
    Elhissi, Abdelbary M.A.
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    Abstract
    This review explores recent advancements in inhaled nanoparticle formulations and inhalation devices, with a focus on various types of nanoparticles used for inhalation to treat inflammatory lung diseases and the types of devices used in their delivery. Medical nebulizers have been found to be the most appropriate type of inhalation devices for the pulmonary delivery of nanoparticles, since formulations can be prepared using straightforward techniques, with no need for liquefied propellants as in the case of pressurized metered dose inhalers (pMDIs), or complicated preparation procedures as in the case of dry powder inhalers (DPIs). We demonstrated examples of how formulations should be designed considering the operation mechanism of nebulizers, and how an interplay of factors can affect the aerosol characteristics of nanoparticle formulations. Overall, nanoparticle-based formulations offer promising potential for the treatment of inflammatory lung diseases due to their unique physicochemical properties and ability to provide localized drug delivery in the lung following inhalation.
    DOI/handle
    http://dx.doi.org/10.3390/pharmaceutics17070893
    http://hdl.handle.net/10576/67607
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    • Pharmacy Research [‎1440‎ items ]

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