Could Vagus nerve stimulation influence bone remodeling?
التاريخ
2021المؤلف
Tamimi, AhmadTamimi, Faleh
Juweid, Malik
Al-Qudah, Abdelkarim A
Al Masri, Amira
Dahbour, Said
Al Bahou, Yakub
Shareef, Abdelatif
Tamimi, Iskandar
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Objectives: To investigate the effect of vagus nerve stimulation (VNS) on the bone mineral density (BMD) in epileptic patients. Methods: A prospective cohort study was conducted on individuals with refractory seizures who underwent VNS surgery between January 2012 and December 2018. BMD was measured preoperatively and between 6 months and one year after surgery. Results: Twenty-one patients (mean age (±SD)=23.6±12.3 years) were recruited for the implantation of a VNS device. The mean absolute increase in lumbar BMD in the 21 patients was 0.04±0.04 g/cm2 resulting in an overall percent increase from baseline of 4.7±6.1%. BMD increased by an amount ≥ the least significant change (LSC) for the lumbar spine in 13 patients (61.9%). The lumbar Z score also increased in these patients from -1.22±1.15 to -0.88±1.22, P=0.006). Pre and Post VNA femoral BMD was measured in only 11 patients and, of those 3 showed a significant increase in BMD, 1 a significant decrease and 7 no change. Conclusion: The implantation of a VNS was associated with an increase in lumbar BMD. This study could lead to a new application for VNS in the treatment of osteoporosis. © 2021, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
معرّف المصادر الموحد
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107319868&partnerID=40&md5=c631dcd4961856ece8a9bbfd1d61f02bDOI/handle
http://hdl.handle.net/10576/31818المجموعات
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