Could Vagus nerve stimulation influence bone remodeling?
المؤلف | Tamimi, Ahmad |
المؤلف | Tamimi, Faleh |
المؤلف | Juweid, Malik |
المؤلف | Al-Qudah, Abdelkarim A |
المؤلف | Al Masri, Amira |
المؤلف | Dahbour, Said |
المؤلف | Al Bahou, Yakub |
المؤلف | Shareef, Abdelatif |
المؤلف | Tamimi, Iskandar |
تاريخ الإتاحة | 2022-05-31T19:01:20Z |
تاريخ النشر | 2021 |
اسم المنشور | Journal of Musculoskeletal Neuronal Interactions |
المصدر | Scopus |
الملخص | Objectives: To investigate the effect of vagus nerve stimulation (VNS) on the bone mineral density (BMD) in epileptic patients. Methods: A prospective cohort study was conducted on individuals with refractory seizures who underwent VNS surgery between January 2012 and December 2018. BMD was measured preoperatively and between 6 months and one year after surgery. Results: Twenty-one patients (mean age (±SD)=23.6±12.3 years) were recruited for the implantation of a VNS device. The mean absolute increase in lumbar BMD in the 21 patients was 0.04±0.04 g/cm2 resulting in an overall percent increase from baseline of 4.7±6.1%. BMD increased by an amount ≥ the least significant change (LSC) for the lumbar spine in 13 patients (61.9%). The lumbar Z score also increased in these patients from -1.22±1.15 to -0.88±1.22, P=0.006). Pre and Post VNA femoral BMD was measured in only 11 patients and, of those 3 showed a significant increase in BMD, 1 a significant decrease and 7 no change. Conclusion: The implantation of a VNS was associated with an increase in lumbar BMD. This study could lead to a new application for VNS in the treatment of osteoporosis. © 2021, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved. |
اللغة | en |
الناشر | International Society of Musculoskeletal and Neuronal Interactions |
الموضوع | adult Article bone density bone remodeling clinical article clinical effectiveness cohort analysis epileptic patient female human male preoperative period prospective study risk factor trend study vagus nerve stimulation young adult bone remodeling osteoporosis Bone Density Bone Remodeling Humans Osteoporosis Prospective Studies Vagus Nerve Stimulation |
النوع | Article |
الصفحات | 255-262 |
رقم العدد | 2 |
رقم المجلد | 21 |
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