Mechanochemical Conversion of Aromatic Amines to Aryl Trifluoromethyl Ethers
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عرض / فتح
التاريخ
2022-06-15المؤلف
Jakubczyk, MichałMkrtchyan, Satenik
Shkoor, Mohanad
Lanka, Suneel
Budzák, Šimon
Iliaš, Miroslav
Skoršepa, Marek
Iaroshenko, Viktor O.
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البيانات الوصفية
عرض كامل للتسجيلةالملخص
Increased interest in the trifluoromethoxy group in organic synthesis and medicinal chemistry has induced a demand for new, selective, general, and faster methods applicable to natural products and highly functionalized compounds at a later stage of hit-to-lead campaigns. Applying pyrylium tetrafluoroborate, we have developed a mechanochemical protocol to selectively substitute the aromatic amino group with the OCF3functionality. The scope of our method includes 31 examples of ring-substituted anilines, including amides and sulfonamides. Expected SNAr products were obtained in excellent yields. The presented concise method opens a pathway to new chemical spaces for the pharmaceutical industry.
معرّف المصادر الموحد
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85132016873&origin=inwardالمجموعات
- الكيمياء وعلوم الأرض [557 items ]