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AuthorSaeed, Muhammad Waqas
AuthorGillani, Syed Wasif
AuthorMahmood, Rana Kamran
AuthorVippadapu, Prasanna
AuthorHussain, Mian Waqar
AuthorRathore, Hassaan Anwer
Available date2022-10-25T06:32:44Z
Publication Date2022
Publication NameBioMed Research International
Identifierhttp://dx.doi.org/10.1155/2022/1639114
CitationSaeed, M. W., Gillani, S. W., Mahmood, R. K., Vippadapu, P., Hussain, M. W., & Rathore, H. A. (2022). A Meta-Analysis on Clinical Outcomes of Ceftolozane versus Piperacillin in Combination with Tazobactam in Patients with Complicated Urinary Tract Infections. BioMed research international, 1-13.
ISSN2314-6133
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85136002846&origin=inward
URIhttp://hdl.handle.net/10576/35397
AbstractObjective. To evaluate efficacy and adverse events of ceftolozane/tazobactam in complicated UTI including acute pyelonephritis. Method. Databases that include PubMed, Embase, Scopus, and TRIP were searched. All randomized controlled trials and cohort studies were considered for the study. Statistical analysis was done using a fixed effects model, and results were expressed in proportion for dichotomous data and risk ratio for continuous data with 95% confidence intervals (CI). Results. A clinical cure of ceftolozane/tazobactam was found to be 92% with 95% CI of 90-94 while that of piperacillin/tazobactam was only 78% (95% CI, 74-82) in patients with complicated UTI. Microbiological eradication was still higher in the ceftolozane/tazobactam group (83%, 95% CI 81-88) when compared with piperacillin/tazobactam (63% 95% CI, 58.77-65.2). Ceftolozane/tazobactam was more effective in the treatment of complicated urinary tract infections other than acute pyelonephritis as compared to piperacillin/tazobactam (RR=1.21, 95% CI, 1.07-1.23). Serious adverse events were found comparable in both groups (RR=1.15, 95% CI, 0.64-2.09). Conclusion. The analysis showed that ceftolozane/tazobactam has better clinical outcomes including cure rates and low resistance for the treatment of complicated urinary tract infection.
Languageen
PublisherHindawi
SubjectMeta-analysis
TitleA Meta-Analysis on Clinical Outcomes of Ceftolozane versus Piperacillin in Combination with Tazobactam in Patients with Complicated Urinary Tract Infections
TypeArticle Review
Pagination1-13
Volume Number2022
ESSN2314-6141
dc.accessType Open Access


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