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المؤلفPatil, Kalyani
المؤلفKhan, Farheen B.
المؤلفAkhtar, Sabah
المؤلفAhmad, Aamir
المؤلفUddin, Shahab
تاريخ الإتاحة2022-10-27T11:34:10Z
تاريخ النشر2021-08
اسم المنشورCancer and Metastasis Reviews
المعرّفhttp://dx.doi.org/10.1007/s10555-021-09979-x
الاقتباسPatil, K., Khan, F. B., Akhtar, S., Ahmad, A., & Uddin, S. (2021). The plasticity of pancreatic cancer stem cells: Implications in therapeutic resistance. Cancer and Metastasis Reviews, 40(3), 691-720.
الرقم المعياري الدولي للكتاب0167-7659
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85113784476&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/35531
الملخصThe ever-growing perception of cancer stem cells (CSCs) as a plastic state rather than a hardwired defined entity has evolved our understanding of the functional and biological plasticity of these elusive components in malignancies. Pancreatic cancer (PC), based on its biological features and clinical evolution, is a prototypical example of a CSC-driven disease. Since the discovery of pancreatic CSCs (PCSCs) in 2007, evidence has unraveled their control over many facets of the natural history of PC, including primary tumor growth, metastatic progression, disease recurrence, and acquired drug resistance. Consequently, the current near-ubiquitous treatment regimens for PC using aggressive cytotoxic agents, aimed at ‘‘tumor debulking’’ rather than eradication of CSCs, have proven ineffective in providing clinically convincing improvements in patients with this dreadful disease. Herein, we review the key hallmarks as well as the intrinsic and extrinsic resistance mechanisms of CSCs that mediate treatment failure in PC and enlist the potential CSC-targeting ‘natural agents’ that are gaining popularity in recent years. A better understanding of the molecular and functional landscape of PCSC-intrinsic evasion of chemotherapeutic drugs offers a facile opportunity for treating PC, an intractable cancer with a grim prognosis and in dire need of effective therapeutic advances.
راعي المشروعMedical Research Center grant no #16354/16, Hamad Medical Corporation, Doha Qatar. Open Access funding is provided by National Library, Doha, Qatar.
اللغةen
الناشرSpringer Nature
الموضوعCancer stem cells
Drug resistance
Epithelial to mesenchymal transition
Oncogenic signaling
Pancreatic cancer
العنوانThe plasticity of pancreatic cancer stem cells: implications in therapeutic resistance
النوعArticle
الصفحات691–720
رقم العدد3
رقم المجلد40
ESSN1573-7233
dc.accessType Open Access


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