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AuthorKalyani, Patil
AuthorKuttikrishnan, Shilpa
AuthorKhan, Abdul Q.
AuthorAhmad, Fareed
AuthorAlam, Majid
AuthorBuddenkotte, Joerg
AuthorAhmad, Aamir
AuthorSteinhoff, Martin
AuthorUddin, Shahab
Available date2023-01-25T06:13:31Z
Publication Date2022-11-30
Publication NameSeminars in Cancer Biology
Identifierhttp://dx.doi.org/10.1016/j.semcancer.2021.12.003
CitationPatil, K., Kuttikrishnan, S., Khan, A. Q., Ahmad, F., Alam, M., Buddenkotte, J., ... & Uddin, S. (2022, November). Molecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways. In Seminars in Cancer Biology (Vol. 86, pp. 382-399). Academic Press.
ISSN1044579X
URIhttps://www.sciencedirect.com/science/article/pii/S1044579X21002960
URIhttp://hdl.handle.net/10576/38841
AbstractCutaneous T cell lymphomas (CTCLs) are a heterogeneous group of lymphoproliferative neoplasms that exhibit a wide spectrum of immune-phenotypical, clinical, and histopathological features. The biology of CTCL is complex and remains elusive. In recent years, the application of next-generation sequencing (NGS) has evolved our understanding of the pathogenetic mechanisms, including genetic aberrations and epigenetic abnormalities that shape the mutational landscape of CTCL and represent one of the important pro-tumorigenic principles in CTCL initiation and progression. Still, identification of the major pathophysiological pathways including genetic and epigenetic components that mediate malignant clonal T cell expansion has not been achieved. This is of prime importance given the role of malignant T cell clones in fostering T helper 2 (Th2)-bias tumor microenvironment and fueling progressive immune dysregulation and tumor cell growth in CTCL patients, manifested by the secretion of Th2-associated cytokines and chemokines. Alterations in malignant cytokine and chemokine expression patterns orchestrate the inflammatory milieu and influence the migration dynamics of malignant clonal T cells. Here, we highlight recent insights about the molecular mechanisms of CTCL pathogenesis, emphasizing the role of cytokines, chemokines, and associated downstream signaling networks in driving immune defects, malignant transformation, and disease progression. In-depth characterization of the CTCL immunophenotype and tumoral microenvironment offers a facile opportunity to expand the therapeutic armamentarium of CTCL, an intractable malignant skin disease with poor prognosis and in dire need of curative treatment approaches.
SponsorMedical Research Center (MRC-01-21-472), Hamad Medical Corporation, Doha, Qatar.
Languageen
PublisherElsevier
SubjectCutaneous T cell lymphoma
Chemokines
Cytokines
Signaling pathways
Sezary syndrome
Mycosis fungoides
Pathophysiology
TitleMolecular pathogenesis of Cutaneous T cell Lymphoma: Role of chemokines, cytokines, and dysregulated signaling pathways
TypeArticle Review
Pagination382-399
Issue Number3
Volume Number86
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN1096-3650
dc.accessType Open Access


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