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المؤلفKawish, Muhammad
المؤلفJabri, Tooba
المؤلفElhissi, Abdelbary
المؤلفZahid, Hina
المؤلفMuhammad Iqbal, Kanwal
المؤلفRao, Komal
المؤلفGul, Jasra
المؤلفAbdullah, Muhammad
المؤلفShah, Muhammad Raza
تاريخ الإتاحة2023-02-28T10:10:26Z
تاريخ النشر2021
اسم المنشورPharmaceutical Development and Technology
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.1080/10837450.2020.1866602
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40532
الملخصThe current study focuses on the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded lactobionic acid (LBA)-functionalized iron oxide magnetic nanoparticles (MNP-LBA). Atomic force microscopy and dynamic light scattering showed that the developed CFT-loaded MNP-LBA is spherical, with a measured hydrodynamic size of 147 ± 15.9 nm and negative zeta potential values (–35 ± 0.58 mV). Fourier transformed infrared analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiencies of 91.5 ± 2.2%, and the drug was released gradually in vitro and shows prolonged in vitro stability using simulated gastrointestinal (GI) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.46 ± 2.5 µg/mL in comparison with its control (1.96 ± 0.58 µg/mL). Overall, the developed MNP-LBA formulation was found promising for provision of high-drug entrapment, gradual drug release and was appropriate for enhancing the oral delivery of CFT.
راعي المشروعThe financial support is from Pakistan Science Foundation for this project through project no PSF/CRP/ NSFC III/Med/S-HEJ (15). The authors would like to thank Pakistan Science Foundation (PSF) and International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan for providing research funding and utilities.
اللغةen
الناشرTaylor and Francis Ltd.
الموضوعbiocompatibility
ceftriaxone
Magnetic NPs
mucoadhesive
oral bioavailability
العنوانGalactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone
النوعArticle
الصفحات291-301
رقم العدد3
رقم المجلد26
dc.accessType Abstract Only


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