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AuthorKawish, Muhammad
AuthorJabri, Tooba
AuthorElhissi, Abdelbary
AuthorZahid, Hina
AuthorMuhammad Iqbal, Kanwal
AuthorRao, Komal
AuthorGul, Jasra
AuthorAbdullah, Muhammad
AuthorShah, Muhammad Raza
Available date2023-02-28T10:10:26Z
Publication Date2021
Publication NamePharmaceutical Development and Technology
ResourceScopus
URIhttp://dx.doi.org/10.1080/10837450.2020.1866602
URIhttp://hdl.handle.net/10576/40532
AbstractThe current study focuses on the development, characterization, biocompatibility investigation and oral bioavailability evaluation of ceftriaxone (CFT)-loaded lactobionic acid (LBA)-functionalized iron oxide magnetic nanoparticles (MNP-LBA). Atomic force microscopy and dynamic light scattering showed that the developed CFT-loaded MNP-LBA is spherical, with a measured hydrodynamic size of 147 ± 15.9 nm and negative zeta potential values (–35 ± 0.58 mV). Fourier transformed infrared analysis revealed interactions between the nanocarrier and the drug. Nanoparticles showed high drug entrapment efficiencies of 91.5 ± 2.2%, and the drug was released gradually in vitro and shows prolonged in vitro stability using simulated gastrointestinal (GI) fluids. The formulations were found to be highly biocompatible (up to 100 µg/mL) and hemocompatible (up to 1.0 mg/mL). Using an albino rabbit model, the formulation showed a significant enhancement in drug plasma concentration up to 14.46 ± 2.5 µg/mL in comparison with its control (1.96 ± 0.58 µg/mL). Overall, the developed MNP-LBA formulation was found promising for provision of high-drug entrapment, gradual drug release and was appropriate for enhancing the oral delivery of CFT.
SponsorThe financial support is from Pakistan Science Foundation for this project through project no PSF/CRP/ NSFC III/Med/S-HEJ (15). The authors would like to thank Pakistan Science Foundation (PSF) and International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan for providing research funding and utilities.
Languageen
PublisherTaylor and Francis Ltd.
Subjectbiocompatibility
ceftriaxone
Magnetic NPs
mucoadhesive
oral bioavailability
TitleGalactosylated iron oxide nanoparticles for enhancing oral bioavailability of ceftriaxone
TypeArticle
Pagination291-301
Issue Number3
Volume Number26
dc.accessType Abstract Only


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