عرض بسيط للتسجيلة

المؤلفXu, Hongyang
المؤلفFan, Minmin
المؤلفElhissi, Abdelbary MA
المؤلفZhang, Zhirong
المؤلفWan, Ka-Wai
المؤلفAhmed, Waqar
المؤلفPhoenix, David A
المؤلفSun, Xun
تاريخ الإتاحة2023-02-28T10:10:26Z
تاريخ النشر2015
اسم المنشورNanomedicine
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.2217/nnm.14.233
معرّف المصادر الموحدhttp://hdl.handle.net/10576/40538
الملخصAim: The graphene oxide (GO) sheet has been considered one of the most promising carbon derivatives in the field of material science for the past few years and has shown excellent tumor-targeting ability, biocompatibility and low toxicity. We have endeavored to conjugate paclitaxel (PTX) to GO molecule and investigate its anticancer efficacy. Materials & Methods: We conjugated the anticancer drug PTX to aminated PEG chains on GO sheets through covalent bonds to get GO-PEG-PTX complexes. The tissue distribution and anticancer efficacy of GO-PEG-PTX were then investigated using a B16 melanoma cancer-bearing C57 mice model. Results: The GO-PEG-PTX complexes exhibited excellent water solubility and biocompatibility. Compared with the traditional formulation of PTX (Taxol), GO-PEG-PTX has shown prolonged blood circulation time as well as high tumor-targeting and -suppressing efficacy. Conclusion: PEGylated graphene oxide is an excellent nanocarrier for paclitaxel for cancer targeting.
اللغةen
الناشرFuture Medicine Ltd.
الموضوعcancer therapy
drug delivery
graphene oxide
paclitaxel
العنوانPEGylated graphene oxide for tumor-targeted delivery of paclitaxel
النوعArticle
الصفحات1247-1262
رقم العدد8
رقم المجلد10
dc.accessType Abstract Only


الملفات في هذه التسجيلة

الملفاتالحجمالصيغةالعرض

لا توجد ملفات لها صلة بهذه التسجيلة.

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة