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AuthorXu, Hongyang
AuthorFan, Minmin
AuthorElhissi, Abdelbary MA
AuthorZhang, Zhirong
AuthorWan, Ka-Wai
AuthorAhmed, Waqar
AuthorPhoenix, David A
AuthorSun, Xun
Available date2023-02-28T10:10:26Z
Publication Date2015
Publication NameNanomedicine
ResourceScopus
URIhttp://dx.doi.org/10.2217/nnm.14.233
URIhttp://hdl.handle.net/10576/40538
AbstractAim: The graphene oxide (GO) sheet has been considered one of the most promising carbon derivatives in the field of material science for the past few years and has shown excellent tumor-targeting ability, biocompatibility and low toxicity. We have endeavored to conjugate paclitaxel (PTX) to GO molecule and investigate its anticancer efficacy. Materials & Methods: We conjugated the anticancer drug PTX to aminated PEG chains on GO sheets through covalent bonds to get GO-PEG-PTX complexes. The tissue distribution and anticancer efficacy of GO-PEG-PTX were then investigated using a B16 melanoma cancer-bearing C57 mice model. Results: The GO-PEG-PTX complexes exhibited excellent water solubility and biocompatibility. Compared with the traditional formulation of PTX (Taxol), GO-PEG-PTX has shown prolonged blood circulation time as well as high tumor-targeting and -suppressing efficacy. Conclusion: PEGylated graphene oxide is an excellent nanocarrier for paclitaxel for cancer targeting.
Languageen
PublisherFuture Medicine Ltd.
Subjectcancer therapy
drug delivery
graphene oxide
paclitaxel
TitlePEGylated graphene oxide for tumor-targeted delivery of paclitaxel
TypeArticle
Pagination1247-1262
Issue Number8
Volume Number10
dc.accessType Abstract Only


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