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AuthorRahim, Muhammad A.
AuthorJan, Nasrullah
AuthorKhan, Safiullah
AuthorShah, Hassan
AuthorMadni, Asadullah
AuthorKhan, Arshad
AuthorJabar, Abdul
AuthorKhan, Shahzeb
AuthorElhissi, Abdelbary
AuthorHussain, Zahid
AuthorAziz, Heather C.
AuthorSohail, Muhammad
AuthorKhan, Mirazam
AuthorThu, Hnin E.
Available date2023-02-28T10:10:26Z
Publication Date2021
Publication NameCancers
ResourceScopus
URIhttp://dx.doi.org/10.3390/cancers13040670
URIhttp://hdl.handle.net/10576/40541
AbstractThe tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been carried out to investigate chemotherapy-based targeted drug delivery, the identification of the most promising strategy capable of bypassing non-specific cytotoxicity is still a major concern. Recent advancements in the arena of onco-targeted therapies have enabled safe and effective tumor-specific localization through stimuli-responsive drug delivery systems. Owing to their promising characteristic features, stimuli-responsive drug delivery platforms have revolutionized the chemotherapy-based treatments with added benefits of enhanced bioavailability and selective cytotoxicity of cancer cells compared to the conventional modalities. The insensitivity of stimuli-responsive drug delivery platforms when exposed to normal cells prevents the release of cytotoxic drugs into the normal cells and therefore alleviates the off-target events associated with chemotherapy. Contrastingly, they showed amplified sensitivity and triggered release of chemotherapeutic payload when internalized into the tumor microenvironment causing maximum cytotoxic responses and the induction of cancer cell necrosis. This review focuses on the physical stimuli-responsive drug delivery systems and chemical stimuli-responsive drug delivery systems for triggered cancer chemotherapy through active and/or passive targeting. Moreover, the review also provided a brief insight into the molecular dynamic simulations associated with stimuli-based tumor targeting.
SponsorThis review article was produced as a part of a project funded by QNRF. The project was made possible by the NPRP grant (grant number 337-3-069) from the Qatar National Research Fund (QNRF; a member of Qatar Foundation). The review conducted is solely the responsibility of the authors.
Languageen
PublisherMDPI AG
SubjectChemotherapy
Prodrugs
Stimuli-responsive drug delivery systems
Tumor
TitleRecent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting
TypeArticle Review
PaginationJan-52
Issue Number4
Volume Number13
dc.accessType Abstract Only


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