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AuthorAmekyeh, Hilda
AuthorAlkhader, Enas
AuthorSabra, Rayan
AuthorBilla, Nashiru
Available date2023-03-20T08:27:23Z
Publication Date2022-01-07
Publication NameMolecules
Identifierhttp://dx.doi.org/10.3390/molecules27020361
CitationAmekyeh, H., Alkhader, E., Sabra, R., & Billa, N. (2022). Prospects of curcumin nanoformulations in cancer management. Molecules, 27(2), 361.
ISSN1420-3049
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85122252256&origin=inward
URIhttp://hdl.handle.net/10576/41201
AbstractThere is increasing interest in the use of natural compounds with beneficial pharmacological effects for managing diseases. Curcumin (CUR) is a phytochemical that is reportedly effective against some cancers through its ability to regulate signaling pathways and protein expression in cancer development and progression. Unfortunately, its use is limited due to its hydrophobicity, low bioavailability, chemical instability, photodegradation, and fast metabolism. Nanoparticles (NPs) are drug delivery systems that can increase the bioavailability of hydrophobic drugs and improve drug targeting to cancer cells via different mechanisms and formulation techniques. In this review, we have discussed various CUR-NPs that have been evaluated for their potential use in treating cancers. Formulations reviewed include lipid, gold, zinc oxide, magnetic, polymeric, and silica NPs, as well as micelles, dendrimers, nanogels, cyclodextrin complexes, and liposomes, with an emphasis on their formulation and characteristics. CUR incorporation into the NPs enhanced its pharmaceutical and therapeutic significance with respect to solubility, absorption, bioavailability, stability, plasma half-life, targeted delivery, and anticancer effect. Our review shows that several CUR-NPs have promising anticancer activity; however, clinical reports on them are limited. We believe that clinical trials must be conducted on CUR-NPs to ensure their effective translation into clinical applications.
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
SubjectBioavailability
Cancer
Chemotherapy
Curcumin
Drug delivery
Nanoparticles
TitleProspects of Curcumin Nanoformulations in Cancer Management
TypeArticle
Issue Number2
Volume Number27
dc.accessType Open Access


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