Natural resorcylic acid lactones: A chemical biology approach for anticancer activity
المؤلف | Shilpa, Kuttikrishnan |
المؤلف | Prabhu, Kirti S. |
المؤلف | Al Sharie, Ahmed H. |
المؤلف | Al Zu'bi, Yazan O. |
المؤلف | Alali, Feras Q. |
المؤلف | Oberlies, Nicholas H. |
المؤلف | Ahmad, Aamir |
المؤلف | El-Elimat, Tamam |
المؤلف | Uddin, Shahab |
تاريخ الإتاحة | 2023-04-12T05:34:39Z |
تاريخ النشر | 2022-02-28 |
اسم المنشور | Drug Discovery Today |
المعرّف | http://dx.doi.org/10.1016/j.drudis.2021.10.001 |
الاقتباس | Kuttikrishnan, Shilpa, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, and Shahab Uddin. "Natural resorcylic acid lactones: A chemical biology approach for anticancer activity." Drug Discovery Today 27, no. 2 (2022): 547-557. |
الرقم المعياري الدولي للكتاب | 13596446 |
الملخص | Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms. |
راعي المشروع | This work is supported by funding from the Medical Research Center (grant no. MRC-01-21-301 (SU)), Hamad Medical Corporation, Doha, Qatar. The authors acknowledge Qatar National Library, Doha, Qatar for supporting Open Access funding for this article. |
اللغة | en |
الناشر | Elsevier |
الموضوع | Resorcylic acid lactones Heat shock protein 90 inhibitors Protein kinase inhibitors Radicicol Hypothemycin 5Z-7-oxo-zeaenol |
النوع | Article |
الصفحات | 547-557 |
رقم العدد | 2 |
رقم المجلد | 27 |
Open Access user License | http://creativecommons.org/licenses/by/4.0/ |
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