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المؤلفShilpa, Kuttikrishnan
المؤلفPrabhu, Kirti S.
المؤلفAl Sharie, Ahmed H.
المؤلفAl Zu'bi, Yazan O.
المؤلفAlali, Feras Q.
المؤلفOberlies, Nicholas H.
المؤلفAhmad, Aamir
المؤلفEl-Elimat, Tamam
المؤلفUddin, Shahab
تاريخ الإتاحة2023-04-12T05:34:39Z
تاريخ النشر2022-02-28
اسم المنشورDrug Discovery Today
المعرّفhttp://dx.doi.org/10.1016/j.drudis.2021.10.001
الاقتباسKuttikrishnan, Shilpa, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, and Shahab Uddin. "Natural resorcylic acid lactones: A chemical biology approach for anticancer activity." Drug Discovery Today 27, no. 2 (2022): 547-557.
الرقم المعياري الدولي للكتاب13596446
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S1359644621004323
معرّف المصادر الموحدhttp://hdl.handle.net/10576/41837
الملخصResorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms.
راعي المشروعThis work is supported by funding from the Medical Research Center (grant no. MRC-01-21-301 (SU)), Hamad Medical Corporation, Doha, Qatar. The authors acknowledge Qatar National Library, Doha, Qatar for supporting Open Access funding for this article.
اللغةen
الناشرElsevier
الموضوعResorcylic acid lactones
Heat shock protein 90 inhibitors
Protein kinase inhibitors
Radicicol
Hypothemycin
5Z-7-oxo-zeaenol
العنوانNatural resorcylic acid lactones: A chemical biology approach for anticancer activity
النوعArticle
الصفحات547-557
رقم العدد2
رقم المجلد27
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Full Text


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