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AuthorShilpa, Kuttikrishnan
AuthorPrabhu, Kirti S.
AuthorAl Sharie, Ahmed H.
AuthorAl Zu'bi, Yazan O.
AuthorAlali, Feras Q.
AuthorOberlies, Nicholas H.
AuthorAhmad, Aamir
AuthorEl-Elimat, Tamam
AuthorUddin, Shahab
Available date2023-04-12T05:34:39Z
Publication Date2022-02-28
Publication NameDrug Discovery Today
Identifierhttp://dx.doi.org/10.1016/j.drudis.2021.10.001
CitationKuttikrishnan, Shilpa, Kirti S. Prabhu, Ahmed H. Al Sharie, Yazan O. Al Zu'bi, Feras Q. Alali, Nicholas H. Oberlies, Aamir Ahmad, Tamam El-Elimat, and Shahab Uddin. "Natural resorcylic acid lactones: A chemical biology approach for anticancer activity." Drug Discovery Today 27, no. 2 (2022): 547-557.
ISSN13596446
URIhttps://www.sciencedirect.com/science/article/pii/S1359644621004323
URIhttp://hdl.handle.net/10576/41837
AbstractResorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid residue (2,4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a broad range of biological activities, including anticancer activities. Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. In this minireview, we focus on natural RALs that possess cytotoxic activities [IC50 values < 10 μM (or 4–5 μg/ml)], discussing their structures, isolation, occurrence, biological activities, and anticancer molecular mechanisms.
SponsorThis work is supported by funding from the Medical Research Center (grant no. MRC-01-21-301 (SU)), Hamad Medical Corporation, Doha, Qatar. The authors acknowledge Qatar National Library, Doha, Qatar for supporting Open Access funding for this article.
Languageen
PublisherElsevier
SubjectResorcylic acid lactones
Heat shock protein 90 inhibitors
Protein kinase inhibitors
Radicicol
Hypothemycin
5Z-7-oxo-zeaenol
TitleNatural resorcylic acid lactones: A chemical biology approach for anticancer activity
TypeArticle
Pagination547-557
Issue Number2
Volume Number27
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Full Text


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