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AuthorNisar, Sabah
AuthorBhat, Ajaz A.
AuthorMasoodi, Tariq
AuthorHashem, Sheema
AuthorAkhtar, Sabah
AuthorAli, Tayyiba Akbar
AuthorAmjad, Sara
AuthorChawla, Sanjeev
AuthorBagga, Puneet
AuthorFrenneaux, Michael P.
AuthorReddy, Ravinder
AuthorFakhro, Khalid
AuthorHaris, Mohammad
Available date2023-04-12T06:23:08Z
Publication Date2022-05-01
Publication NameMolecular Psychiatry
Identifierhttp://dx.doi.org/10.1038/s41380-022-01506-w
CitationNisar, S., Bhat, A.A., Masoodi, T. et al. Genetics of glutamate and its receptors in autism spectrum disorder. Mol Psychiatry 27, 2380–2392 (2022). https://doi.org/10.1038/s41380-022-01506-w
ISSN13594184
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85126274476&origin=inward
URIhttp://hdl.handle.net/10576/41840
AbstractAutism spectrum disorder (ASD) is a neurodevelopmental impairment characterized by deficits in social interaction skills, impaired communication, and repetitive and restricted behaviors that are thought to be due to altered neurotransmission processes. The amino acid glutamate is an essential excitatory neurotransmitter in the human brain that regulates cognitive functions such as learning and memory, which are usually impaired in ASD. Over the last several years, increasing evidence from genetics, neuroimaging, protein expression, and animal model studies supporting the notion of altered glutamate metabolism has heightened the interest in evaluating glutamatergic dysfunction in ASD. Numerous pharmacological, behavioral, and imaging studies have demonstrated the imbalance in excitatory and inhibitory neurotransmitters, thus revealing the involvement of the glutamatergic system in ASD pathology. Here, we review the effects of genetic alterations on glutamate and its receptors in ASD and the role of non-invasive imaging modalities in detecting these changes. We also highlight the potential therapeutic targets associated with impaired glutamatergic pathways.
Languageen
PublisherSpringer Nature
SubjectGenetics
Neuroscience
TitleGenetics of glutamate and its receptors in autism spectrum disorder
TypeArticle Review
Pagination2380-2392
Issue Number5
Volume Number27
ESSN1476-5578
dc.accessType Open Access


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