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Medicine Research [1819 items ]
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Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders
( Frontiers Media , 2022 , Article)The ryanodine receptor (RyR) is a homotetrameric channel mediating sarcoplasmic reticulum Ca<sup>2+</sup> release required for skeletal and cardiac muscle contraction. Mutations in RyR1 and RyR2 lead to life-threatening ... -
Disparate molecular mechanisms in cardiac ryanodine receptor channelopathies
( Frontiers Media , 2024 , Article)Aims: Mutations in the cardiac ryanodine receptor (RyR2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). This study investigates the underlying molecular mechanisms for CPVT mutations ... -
The 6th Qatar International Internal Medicine (6-QIIM) Conference 2025: Enhancing patient care through regional and international collaboration and innovation
( HBKU Press , 2025 , Other)Internal Medicine has witnessed remarkable advancements in recent years, encompassing telemedicine, personalized medicine, and artificial intelligence. However, significant challenges persist. Noncommunicable diseases such ... -
Microneedle Delivery of Heterologous Microparticulate COVID-19 Vaccine Induces Cross Strain Specific Antibody Levels in Mice
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: In recent years, the COVID-19 pandemic has significantly impacted global health, largely driven by the emergence of various genetic mutations within the SARS-CoV-2 virus. Although the pandemic phase has passed, ... -
Impact of polypharmacy phenogroups on different heart failure phenotypes in patients with chronic heart failure: a retrospective examination of real-world cohort
( Frontiers Media S.A. , 2025 , Article)Background: Polypharmacy is a rising morbidity amongst patients with chronic heart failure (CHF), with reported prevalence ranging from 70% to 85%. While polypharmacy is essential for managing comorbid conditions, its exact ... -
Gum Acacia supplementation improves adiponectin levels and HbA1c/adiponectin ratio in women with type 2 diabetes: A randomized controlled trial
( Functional Food Center Inc. , 2025 , Article)Background: Adiponectin contributes to the regulation of glucose homeostasis and lipid profiles and plays a role in maintaining average body weight. At high serum concentrations, adiponectin sensitizes cells to insulin and ... -
Rethinking the Diagnosis and Management of Antibody-Mediated Rejection in Multidisciplinary Transplant Meetings: A Global Survey and Banff Working Group Recommendations
( John Wiley & Sons , 2025 , Article)Introduction: The diagnosis of antibody-mediated rejection (AMR) requires input from several transplant professionals. Bringing clinical and laboratory experts together may help standardize care. Yet, little is known about ... -
Leveraging Machine and Deep Learning Algorithms for hERG Blocker Prediction
( Institute of Electrical and Electronics Engineers Inc. (IEEE) , 2025 , Article)The human ether-a-go-go-related (hERG) gene is crucial in enabling the regulation of repolarisation process in the heart. Some chemicals act as hERG blockers, resulting in prolonged QT intervals. Predicting the binding ... -
Direct and indirect estimation of stature using measurements of metacarpals of South Africans of African descent
( Springer Nature , 2025 , Article)Background: Stature reconstruction is an important component of skeletal analysis in personal identification. The mathematical method has been used in various parts of the world to establish standards for estimation of ... -
Comparison between flexible and navigable suction ureteral access sheath and standard ureteral access sheath during flexible ureteroscopy for the management of kidney stone: systematic review and meta-analysis
( Springer Nature , 2025 , Article)Objectives: Flexible ureteroscopy (FURS) is a commonly chosen technique for kidney stone treatment. The use of ureteral access sheaths (UAS) enhances both access and the procedure's effectiveness. This study performs a ... -
Psychosocial Evaluation of Prospective Living Kidney Donors in Qatar: A Profile of Prospective Donors, Process, and Outcomes
( Wolters Kluwer Health , 2025 , Article)Background. In Qatar, the Committee for Oversight of Living Donation (COLD) was established at Hamad Medical Corporation in 2014 to provide standardized, multidisciplinary psychosocial evaluation (PE) for prospective living ... -
Digital twins for the era of personalized surgery
( Springer Nature , 2025 , Article)Digital twins can aid surgeons in training and in performing interventions with greater awareness and precision. The range and variety of digital twins in surgery are described, and their use across perioperative care is ... -
Kounis syndrome: acute myocardial injury triggered by ant bite-induced anaphylaxis
( Oxford University Press , 2025 , Article)Anaphylaxis triggered by insect bites is well-documented, but its association with acute myocardial injury (AMI) is rare. We report a case of Kounis syndrome, where an ant bite induced anaphylaxis and myocardial injury. A ... -
From Knowledge to Habits: Changes in COVID-19 Health Attitudes, Practices, and Sources of Information (HAPS) at Qatar University Post-Pandemic.
( Wiley , 2025 , Article)The COVID-19 pandemic has profoundly impacted health behaviors globally and this study investigated changes in Health, Attitudes, Practices, and Sources of information (HAPS) among 1186 students, faculty, and staff at Qatar ... -
Changing life expectancy in European countries 1990–2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021
( Elsevier , 2025 , Article)BackgroundDecades of steady improvements in life expectancy in Europe slowed down from around 2011, well before the COVID-19 pandemic, for reasons which remain disputed. We aimed to assess how changes in risk factors and ... -
Association of physical activity level during pregnancy with preterm birth and infant adiposity: longitudinal analysis from the MAASTHI cohort, India
( Springer Nature , 2025 , Article)Background: Physical activity during pregnancy is thought to influence birth outcomes, but its association with it is not fully understood. We aimed to examine the association of sedentary behavior during pregnancy with ... -
The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages
( Microbiology Society , 2025 , Article)The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced ... -
Shaping the future of cell and gene therapy workforce development: training of cell therapy processing personnel - perspectives from the International Society for Cell & Gene Therapy Lab Practices Committee
( Elsevier , 2025 , Article)BackgroundThe field of cell and gene therapy (CGT) is expanding at a rapid rate. CGT workforce shortage is a growing concern, and high-quality training programs are essential to keep up with the increasing demand for ... -
Prospective registration was associated with a reduced risk of bias for randomized controlled trials: a meta-research study
( Elsevier , 2025 , Article)ObjectivesTo investigate the association between trial registration and the risk of bias (RoB). Study Design and SettingsRandomized controlled trials (RCTs) from systematic reviews of medication-related harm published ... -
Proteomic analysis reveals potential biomarker candidates in serous ovarian tumors – a preliminary study
( Termedia Publishing House Ltd. , 2025 , Article)Introduction: Ovarian serous cystadenocarcinoma (SCA), a deadly gynecologic cancer, often goes undetected until the late stages. Tissue proteomics unveils disease heterogeneity, enhancing tumor classification and enabling ...
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