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المؤلفAboukhater, Diana
المؤلفMorad, Bassel
المؤلفNasrallah, Nadim
المؤلفNasser, Suzanne A.
المؤلفSahebkar, Amirhossein
المؤلفKobeissy, Firas
المؤلفBoudaka, Ammar
المؤلفEid, Ali H.
تاريخ الإتاحة2023-05-12T12:04:48Z
تاريخ النشر2023-01-01
اسم المنشورJournal of Cellular Physiology
المعرّفhttp://dx.doi.org/10.1002/jcp.31019
الاقتباسAboukhater, D., Morad, B., Nasrallah, N., Nasser, S. A., Sahebkar, A., Kobeissy, F., ... & Eid, A. H. (2023). Inflammation and hypertension: Underlying mechanisms and emerging understandings. Journal of Cellular Physiology.‏
الرقم المعياري الدولي للكتاب00219541
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152449325&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/42653
الملخصHypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive response against some homeostatic imbalances, inflammation, when dysregulated, can be very deleterious. In this review, we highlight and discuss the causative relationship between inflammation and hypertension. We critically discuss how the interplay between inflammation and reactive oxygen species evokes endothelial damage and dysfunction, ultimately leading to narrowing and stiffness of blood vessels. This, along with phenotypic switching of the vascular smooth muscle cells and the abnormal increase in extracellular matrix deposition further exacerbates arterial stiffness and noncompliance. We also discuss how hyperhomocysteinemia and microRNA act as links between inflammation and hypertension. The premises we discuss suggest that the blue-sky scenarios for targeting the underlying mechanisms of hypertension necessitate further research.
اللغةen
الناشرwiley online library
الموضوعcardiovascular disease
cytokines
endothelium
microRNA
vascular smooth muscle
العنوانInflammation and hypertension: Underlying mechanisms and emerging understandings
النوعArticle Review
dc.accessType Abstract Only


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