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AuthorAboukhater, Diana
AuthorMorad, Bassel
AuthorNasrallah, Nadim
AuthorNasser, Suzanne A.
AuthorSahebkar, Amirhossein
AuthorKobeissy, Firas
AuthorBoudaka, Ammar
AuthorEid, Ali H.
Available date2023-05-12T12:04:48Z
Publication Date2023-01-01
Publication NameJournal of Cellular Physiology
Identifierhttp://dx.doi.org/10.1002/jcp.31019
CitationAboukhater, D., Morad, B., Nasrallah, N., Nasser, S. A., Sahebkar, A., Kobeissy, F., ... & Eid, A. H. (2023). Inflammation and hypertension: Underlying mechanisms and emerging understandings. Journal of Cellular Physiology.‏
ISSN00219541
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152449325&origin=inward
URIhttp://hdl.handle.net/10576/42653
AbstractHypertension remains a major contributor to cardiovascular disease (CVD), a leading cause of global death. One of the major insults that drive increased blood pressure is inflammation. While it is the body's defensive response against some homeostatic imbalances, inflammation, when dysregulated, can be very deleterious. In this review, we highlight and discuss the causative relationship between inflammation and hypertension. We critically discuss how the interplay between inflammation and reactive oxygen species evokes endothelial damage and dysfunction, ultimately leading to narrowing and stiffness of blood vessels. This, along with phenotypic switching of the vascular smooth muscle cells and the abnormal increase in extracellular matrix deposition further exacerbates arterial stiffness and noncompliance. We also discuss how hyperhomocysteinemia and microRNA act as links between inflammation and hypertension. The premises we discuss suggest that the blue-sky scenarios for targeting the underlying mechanisms of hypertension necessitate further research.
Languageen
Publisherwiley online library
Subjectcardiovascular disease
cytokines
endothelium
microRNA
vascular smooth muscle
TitleInflammation and hypertension: Underlying mechanisms and emerging understandings
TypeArticle Review
dc.accessType Abstract Only


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