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AuthorBashraheel, Sara S.
AuthorKheraldine, Hadeel
AuthorKhalaf, Sarah
AuthorMoustafa, Ala Eddin Al
Available date2023-05-13T11:07:57Z
Publication Date2023-06-01
Publication NameBiomedicine and Pharmacotherapy
Identifierhttp://dx.doi.org/10.1016/j.biopha.2023.114676
CitationBashraheel, S. S., Kheraldine, H., Khalaf, S., & Al Moustafa, A. E. (2023). Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications. Biomedicine & Pharmacotherapy, 162, 114676.‏
ISSN07533322
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152704906&origin=inward
URIhttp://hdl.handle.net/10576/42656
AbstractDue to the strong association between diabetes and cancer incidents, several anti-diabetic drugs, including metformin, have been examined for their anticancer activity. Metformin is a biguanide antihyperglycemic agent used as a first-line drug for type II diabetes mellitus. It exhibits anticancer activity by impacting different molecular pathways, such as AMP-inducible protein kinase (AMPK)-dependent and AMPK-independent pathways. Additionally, Metformin indirectly inhibits IGF-1R signaling, which is highly activated in breast malignancy. On the other hand, breast cancer is one of the major causes of cancer-related morbidity and mortality worldwide, where the human epidermal growth factor receptor-positive (HER2-positive) subtype is one of the most aggressive ones with a high rate of lymph node metastasis. In this review, we summarize the association between diabetes and human cancer, listing recent evidence of metformin's anticancer activity. A special focus is dedicated to HER2-positive breast cancer with regards to the interaction between HER2 and IGF-1R. Then, we discuss combination therapy strategies of metformin and other anti-diabetic drugs in HER2-positive breast cancer.
Languageen
PublisherElsevier
SubjectBreast cancer
Diabetes
HER2
HER2/IGF-1R interaction
Metformin
TitleMetformin and HER2-positive breast cancer: Mechanisms and therapeutic implications
TypeArticle
Volume Number162
dc.accessType Open Access


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