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AuthorAlizadeh, Javad
AuthorKavoosi, Mahboubeh
AuthorSingh, Navjit
AuthorLorzadeh, Shahrokh
AuthorRavandi, Amir
AuthorKidane, Biniam
AuthorAhmed, Naseer
AuthorMraiche, Fatima
AuthorMowat, Michael R.
AuthorGhavami, Saeid
Available date2023-06-18T10:32:23Z
Publication Date2023-04-07
Publication NameCancers
Identifierhttp://dx.doi.org/10.3390/cancers15082195
CitationAlizadeh, J., Kavoosi, M., Singh, N., Lorzadeh, S., Ravandi, A., Kidane, B., ... & Ghavami, S. (2023). Regulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer.
ISSN2072-6694
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85153960068&origin=inward
URIhttp://hdl.handle.net/10576/44515
AbstractMetabolic changes are an important component of tumor cell progression. Tumor cells adapt to environmental stresses via changes to carbohydrate and lipid metabolism. Autophagy, a physiological process in mammalian cells that digests damaged organelles and misfolded proteins via lysosomal degradation, is closely associated with metabolism in mammalian cells, acting as a meter of cellular ATP levels. In this review, we discuss the changes in glycolytic and lipid biosynthetic pathways in mammalian cells and their impact on carcinogenesis via the autophagy pathway. In addition, we discuss the impact of these metabolic pathways on autophagy in lung cancer.
SponsorCancerCare Manitoba Foundation - grant No. (763117252)
Languageen
PublisherMultidisciplinary Digital Publishing Institute (MDPI)
SubjectBcl2 family protein
ceramide metabolism
glycolysis
mitophagy
non-small cell lung carcinoma
Warburg effect
TitleRegulation of Autophagy via Carbohydrate and Lipid Metabolism in Cancer
TypeArticle
Issue Number8
Volume Number15
dc.accessType Open Access


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