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المؤلفHajipour, Mohammad J.
المؤلفSafavi-Sohi, Reihaneh
المؤلفSharifi, Shahriar
المؤلفMahmoud, Nouf
المؤلفAshkarran, Ali Akbar
المؤلفVoke, Elizabeth
المؤلفSerpooshan, Vahid
المؤلفRamezankhani, Milad
المؤلفMilani, Abbas S.
المؤلفLandry, Markita P.
المؤلفMahmoudi, Morteza
تاريخ الإتاحة2023-06-19T10:24:47Z
تاريخ النشر2023-04-29
اسم المنشورSmall
المعرّفhttp://dx.doi.org/10.1002/smll.202301838
الاقتباسHajipour, M. J., Safavi‐Sohi, R., Sharifi, S., Mahmoud, N., Ashkarran, A. A., Voke, E., ... & Mahmoudi, M. (2023). An Overview of Nanoparticle Protein Corona Literature. Small, 2301838.
الرقم المعياري الدولي للكتاب1613-6810
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85153778527&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/44578
الملخصThe protein corona forms spontaneously on nanoparticle surfaces when nanomaterials are introduced into any biological system/fluid. Reliable characterization of the protein corona is, therefore, a vital step in the development of safe and efficient diagnostic and therapeutic nanomedicine products. 2134 published manuscripts on the protein corona are reviewed and a down-selection of 470 papers spanning 2000–2021, comprising 1702 nanoparticle (NP) systems is analyzed. This analysis reveals: i) most corona studies have been conducted on metal and metal oxide nanoparticles; ii) despite their overwhelming presence in clinical practice, lipid-based NPs are underrepresented in protein corona research, iii) studies use new methods to improve reliability and reproducibility in protein corona research; iv) studies use more specific protein sources toward personalized medicine; and v) careful characterization of nanoparticles after corona formation is imperative to minimize the role of aggregation and protein contamination on corona outcomes. As nanoparticles used in biomedicine become increasingly prevalent and biochemically complex, the field of protein corona research will need to focus on developing analytical approaches and characterization techniques appropriate for each unique nanoparticle formulation. Achieving such characterization of the nano-bio interface of nanobiotechnologies will enable more seamless development and safe implementation of nanoparticles in medicine.
راعي المشروعThis project is supported by the US National Institute of Diabetes and Digestive and Kidney Diseases (grant DK131417) (to M.M.).
اللغةen
الناشرWiley-Blackwell
الموضوعanalytical chemistry
characterization
nanomedicine
protein corona
reproducibility
standard procedures
العنوانAn Overview of Nanoparticle Protein Corona Literature
النوعArticle
ESSN1613-6829
dc.accessType Open Access


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