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المؤلفAl-Haidose, Amal
المؤلفYassin, Mohamed A.
المؤلفAhmed, Muna N.
المؤلفKunhipurayil, Hasna H.
المؤلفAl-Harbi, Asrar A.
المؤلفAljaberi, Musheer A.
المؤلفAbbasi, Saddam A.
المؤلفKordasti, Shahram
المؤلفAbdallah, Atiyeh M.
تاريخ الإتاحة2023-06-19T11:32:12Z
تاريخ النشر2023-04-12
اسم المنشورJournal of Clinical Medicine
المعرّفhttp://dx.doi.org/10.3390/jcm12082832
الاقتباسAl-Haidose, A., Yassin, M. A., Ahmed, M. N., Kunhipurayil, H. H., Al-Harbi, A. A., Aljaberi, M. A., ... & Abdallah, A. M. (2023). Distinct Clinical and Prognostic Features of Myelodysplastic Syndrome in Patients from the Middle East, North Africa, and Beyond: A Systemic Review. Journal of Clinical Medicine, 12(8), 2832.
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85154591095&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/44583
الملخصMyelodysplastic syndrome (MDS) describes a group of bone marrow malignancies with variable morphologies and heterogeneous clinical features. The aim of this study was to systematically appraise the published clinical, laboratory, and pathologic characteristics and identify distinct clinical features of MDS in the Middle East and North Africa (MENA) region. We conducted a comprehensive search of the PubMed, Web of Science, EMBASE, and Cochrane Library databases from 2000 to 2021 to identify population-based studies of MDS epidemiology in MENA countries. Of 1935 studies, 13 independent studies published between 2000 and 2021 representing 1306 patients with MDS in the MENA region were included. There was a median of 85 (range 20 to 243) patients per study. Seven studies were performed in Asian MENA countries (732 patients, 56%) and six in North African MENA countries (574 patients, 44%). The pooled mean age was 58.4 years (SD 13.14; 12 studies), and the male-to-female ratio was 1.4. The distribution of WHO MDS subtypes was significantly different between MENA, Western, and Far East populations (n = 978 patients, p < 0.001). More patients from MENA countries were at high/very high IPSS risk than in Western and Far East populations (730 patients, p < 0.001). There were 562 patients (62.2%) with normal karyotypes and 341 (37.8%) with abnormal karyotypes. Our findings establish that MDS is prevalent within the MENA region and is more severe than in Western populations. MDS appears to be more severe with an unfavorable prognosis in the Asian MENA population than the North African MENA population.
راعي المشروعThis publication was supported by Qatar University, internal grants no. QUCP-CHS-2022-551 and QUST-1 CHS-2023-838, Qatar University.
اللغةen
الناشرMultidisciplinary Digital Publishing Institute (MDPI)
الموضوعAsia
cytogenetics
epidemiology
MENA
myelodysplastic syndrome
North Africa
prognosis
العنوانDistinct Clinical and Prognostic Features of Myelodysplastic Syndrome in Patients from the Middle East, North Africa, and Beyond: A Systemic Review
النوعArticle
رقم العدد8
رقم المجلد12
ESSN2077-0383
dc.accessType Open Access


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