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المؤلفParveen, Salahuddin
المؤلفFatima, Munazza Tamkeen
المؤلفUversky, Vladimir N.
المؤلفKhan, Rizwan Hasan
المؤلفIslam, Zeyaul
المؤلفFurkan, Mohammad
تاريخ الإتاحة2023-07-27T07:43:57Z
تاريخ النشر2021-09-02
اسم المنشورInternational Journal of Biological Macromolecules
المعرّفhttp://dx.doi.org/10.1016/j.ijbiomac.2021.08.197
الاقتباسSalahuddin, P., Fatima, M. T., Uversky, V. N., Khan, R. H., Islam, Z., & Furkan, M. (2021). The role of amyloids in Alzheimer's and Parkinson's diseases. International Journal of Biological Macromolecules, 190, 44-55.
الرقم المعياري الدولي للكتاب0141-8130
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0141813021018729
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46363
الملخصWith varying clinical symptoms, most neurodegenerative diseases are associated with abnormal loss of neurons. They share the same common pathogenic mechanisms involving misfolding and aggregation, and these visible aggregates of proteins are deposited in the central nervous system. Amyloid formation is thought to arise from partial unfolding of misfolded proteins leading to the exposure of hydrophobic surfaces, which interact with other similar structures and give rise to form dimers, oligomers, protofibrils, and eventually mature fibril aggregates. Accumulating evidence indicates that amyloid oligomers, not amyloid fibrils, are the most toxic species that causes Alzheimer's disease (AD) and Parkinson's disease (PD). AD has recently been recognized as the ‘twenty-first century plague’, with an incident rate of 1% at 60 years of age, which then doubles every fifth year. Currently, 5.3 million people in the US are afflicted with this disease, and the number of cases is expected to rise to 13.5 million by 2050. PD, a disorder of the brain, is the second most common form of dementia, characterized by difficulty in walking and movement. Keeping the above views in mind, in this review we have focused on the roles of amyloid in neurodegenerative diseases including AD and PD, the involvement of amyloid in mitochondrial dysfunction leading to neurodegeneration, are also considered in the review.
اللغةen
الناشرElsevier
الموضوعAmyloid fibrils
Amyloid oligomers
Alzheimer's disease
Parkinson's disease
α-Synuclein
العنوانThe role of amyloids in Alzheimer's and Parkinson's diseases
النوعArticle
الصفحات44-55
رقم المجلد190
ESSN1879-0003
dc.accessType Open Access


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