Show simple item record

AuthorParveen, Salahuddin
AuthorFatima, Munazza Tamkeen
AuthorUversky, Vladimir N.
AuthorKhan, Rizwan Hasan
AuthorIslam, Zeyaul
AuthorFurkan, Mohammad
Available date2023-07-27T07:43:57Z
Publication Date2021-09-02
Publication NameInternational Journal of Biological Macromolecules
Identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2021.08.197
CitationSalahuddin, P., Fatima, M. T., Uversky, V. N., Khan, R. H., Islam, Z., & Furkan, M. (2021). The role of amyloids in Alzheimer's and Parkinson's diseases. International Journal of Biological Macromolecules, 190, 44-55.
ISSN0141-8130
URIhttps://www.sciencedirect.com/science/article/pii/S0141813021018729
URIhttp://hdl.handle.net/10576/46363
AbstractWith varying clinical symptoms, most neurodegenerative diseases are associated with abnormal loss of neurons. They share the same common pathogenic mechanisms involving misfolding and aggregation, and these visible aggregates of proteins are deposited in the central nervous system. Amyloid formation is thought to arise from partial unfolding of misfolded proteins leading to the exposure of hydrophobic surfaces, which interact with other similar structures and give rise to form dimers, oligomers, protofibrils, and eventually mature fibril aggregates. Accumulating evidence indicates that amyloid oligomers, not amyloid fibrils, are the most toxic species that causes Alzheimer's disease (AD) and Parkinson's disease (PD). AD has recently been recognized as the ‘twenty-first century plague’, with an incident rate of 1% at 60 years of age, which then doubles every fifth year. Currently, 5.3 million people in the US are afflicted with this disease, and the number of cases is expected to rise to 13.5 million by 2050. PD, a disorder of the brain, is the second most common form of dementia, characterized by difficulty in walking and movement. Keeping the above views in mind, in this review we have focused on the roles of amyloid in neurodegenerative diseases including AD and PD, the involvement of amyloid in mitochondrial dysfunction leading to neurodegeneration, are also considered in the review.
Languageen
PublisherElsevier
SubjectAmyloid fibrils
Amyloid oligomers
Alzheimer's disease
Parkinson's disease
α-Synuclein
TitleThe role of amyloids in Alzheimer's and Parkinson's diseases
TypeArticle
Pagination44-55
Volume Number190
ESSN1879-0003
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record