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المؤلفParveen, Salahuddin
المؤلفKhan, Rizwan Hasan
المؤلفFurkan, Mohammad
المؤلفUversky, Vladimir N.
المؤلفIslam, Zeyaul
المؤلفFatima, Munazza Tamkeen
تاريخ الإتاحة2023-07-30T11:58:03Z
تاريخ النشر2021-07-14
اسم المنشورInternational Journal of Biological Macromolecules
المعرّفhttp://dx.doi.org/10.1016/j.ijbiomac.2021.07.056
الاقتباسSalahuddin, P., Khan, R. H., Furkan, M., Uversky, V. N., Islam, Z., & Fatima, M. T. (2021). Mechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies. International Journal of Biological Macromolecules, 186, 580-590.
الرقم المعياري الدولي للكتاب0141-8130
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S0141813021014938
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46407
الملخصProtein misfolding and aggregation can be induced by a wide variety of factors, such as dominant disease-associated mutations, changes in the environmental conditions (pH, temperature, ionic strength, protein concentration, exposure to transition metal ions, exposure to toxins, posttranslational modifications including glycation, phosphorylation, and sulfation). Misfolded intermediates interact with similar intermediates and progressively form dimers, oligomers, protofibrils, and fibrils. In amyloidoses, fibrillar aggregates are deposited in the tissues either as intracellular inclusion or extracellular plaques (amyloid). When such proteinaceous deposit occurs in the neuronal cells, it initiates degeneration of neurons and consequently resulting in the manifestation of various neurodegenerative diseases. Several different types of molecules have been designed and tested both in vitro and in vivo to evaluate their anti-amyloidogenic efficacies. For instance, the native structure of a protein associated with amyloidosis could be stabilized by ligands, antibodies could be used to remove plaques, oligomer-specific antibody A11 could be used to remove oligomers, or prefibrillar aggregates could be removed by affibodies. Keeping the above views in mind, in this review we have discussed protein misfolding and aggregation, mechanisms of protein aggregation, factors responsible for aggregations, and strategies for aggregation inhibition.
اللغةen
الناشرElsevier
الموضوعAlzheimer's disease
Amyloidosis
Blood brain barrier
Mechanisms of protein aggregation
Protein aggregation
العنوانMechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies
النوعArticle
الصفحات580-590
رقم المجلد186
ESSN1879-0003
dc.accessType Open Access


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