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AuthorParveen, Salahuddin
AuthorKhan, Rizwan Hasan
AuthorFurkan, Mohammad
AuthorUversky, Vladimir N.
AuthorIslam, Zeyaul
AuthorFatima, Munazza Tamkeen
Available date2023-07-30T11:58:03Z
Publication Date2021-07-14
Publication NameInternational Journal of Biological Macromolecules
Identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2021.07.056
CitationSalahuddin, P., Khan, R. H., Furkan, M., Uversky, V. N., Islam, Z., & Fatima, M. T. (2021). Mechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies. International Journal of Biological Macromolecules, 186, 580-590.
ISSN0141-8130
URIhttps://www.sciencedirect.com/science/article/pii/S0141813021014938
URIhttp://hdl.handle.net/10576/46407
AbstractProtein misfolding and aggregation can be induced by a wide variety of factors, such as dominant disease-associated mutations, changes in the environmental conditions (pH, temperature, ionic strength, protein concentration, exposure to transition metal ions, exposure to toxins, posttranslational modifications including glycation, phosphorylation, and sulfation). Misfolded intermediates interact with similar intermediates and progressively form dimers, oligomers, protofibrils, and fibrils. In amyloidoses, fibrillar aggregates are deposited in the tissues either as intracellular inclusion or extracellular plaques (amyloid). When such proteinaceous deposit occurs in the neuronal cells, it initiates degeneration of neurons and consequently resulting in the manifestation of various neurodegenerative diseases. Several different types of molecules have been designed and tested both in vitro and in vivo to evaluate their anti-amyloidogenic efficacies. For instance, the native structure of a protein associated with amyloidosis could be stabilized by ligands, antibodies could be used to remove plaques, oligomer-specific antibody A11 could be used to remove oligomers, or prefibrillar aggregates could be removed by affibodies. Keeping the above views in mind, in this review we have discussed protein misfolding and aggregation, mechanisms of protein aggregation, factors responsible for aggregations, and strategies for aggregation inhibition.
Languageen
PublisherElsevier
SubjectAlzheimer's disease
Amyloidosis
Blood brain barrier
Mechanisms of protein aggregation
Protein aggregation
TitleMechanisms of amyloid proteins aggregation and their inhibition by antibodies, small molecule inhibitors, nano-particles and nano-bodies
TypeArticle
Pagination580-590
Volume Number186
ESSN1879-0003
dc.accessType Open Access


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