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المؤلفJithesh, Puthen Veettil
المؤلفAbuhaliqa, Mohammed
المؤلفSyed, Najeeb
المؤلفAhmed, Ikhlak
المؤلفEl Anbari, Mohammed
المؤلفBastaki, Kholoud
المؤلفSherif, Shimaa
المؤلفUmlai, Umm-Kulthum
المؤلفJan, Zainab
المؤلفGandhi, Geethanjali
المؤلفManickam, Chidambaram
المؤلفSelvaraj, Senthil
المؤلفGeorge, Chinnu
المؤلفBangarusamy, Dhinoth
المؤلفAbdel-latif, Rania
المؤلفAl-Shafai, Mashael
المؤلفTatari-Calderone, Zohreh
المؤلفEstivill, Xavier
المؤلفPirmohamed, Munir
المؤلفAbdel-latif, Rania
المؤلفSaqri, Tariq Abu
المؤلفZaid, Tariq Abu
المؤلفAfifi, Nahla
المؤلفAl-Ali, Rashid
المؤلفAl-Khodor, Souhaila
المؤلفAl-Muftah, Wadha
المؤلفAl-Sarraj, Yasser
المؤلفAlbagha, Omar
المؤلفAlkhayat, Eiman
المؤلفAlkuwari, Fatima
المؤلفAlmabrazi, Hakeem
المؤلفAlshafai, Mashael
المؤلفAlthani, Asmaa
المؤلفAlvi, Muhammad
المؤلفBadii, Ramin
المؤلفBadji, Radja
المؤلفChouchane, Lotfi
المؤلفDarwish, Dima
المؤلفEl Khouly, Ahmed
المؤلفEnnaifar, Maryem
المؤلفEstivill, Xavier
المؤلفFadl, Tasnim
المؤلفFakhro, Khalid
المؤلفFethnou, Eleni
المؤلفHamza, Mehshad
المؤلفIsmail, Said I.
المؤلفJithesh, Puthen V.
المؤلفKhatib, Mohammedhusen
المؤلفLiu, Wei
المؤلفLorenz, Stephan
المؤلفMbarek, Hamdi
المؤلفMokrab, Younes
المؤلفPathare, Tushar
المؤلفPoolat, Shafeeq
المؤلفQafoud, Fatima
المؤلفVempalli, Fazulur Rehaman
المؤلفSaad, Chadi
المؤلفSuhre, Karsten
المؤلفSyed, Najeeb
المؤلفTatari, Zohreh
المؤلفTemanni, Ramzi
المؤلفTomei, Sara
المؤلفYasin, Heba
تاريخ الإتاحة2023-08-28T09:09:49Z
تاريخ النشر2022
اسم المنشورnpj Genomic Medicine
المصدرScopus
الرقم المعياري الدولي للكتاب20567944
معرّف المصادر الموحدhttp://dx.doi.org/10.1038/s41525-022-00281-5
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46830
الملخصClinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is lagging in many parts of the world, including the Middle East, mainly due to the lack of data on the distribution of actionable pharmacogenomic variation in these ethnicities. We analyzed 6,045 whole genomes from the Qatari population for the distribution of allele frequencies of 2,629 variants in 1,026 genes known to affect 559 drugs or classes of drugs. We also performed a focused analysis of genotypes or diplotypes of 15 genes affecting 46 drugs, which have guidelines for clinical implementation and predicted their phenotypic impact. The allele frequencies of 1,320 variants in 703 genes affecting 299 drugs or class of drugs were significantly different between the Qatari population and other world populations. On average, Qataris carry 3.6 actionable genotypes/diplotypes, affecting 13 drugs with guidelines for clinical implementation, and 99.5% of the individuals had at least one clinically actionable genotype/diplotype. Increased risk of simvastatin-induced myopathy could be predicted in ~32% of Qataris from the diplotypes of SLCO1B1, which is higher compared to many other populations, while fewer Qataris may need tacrolimus dosage adjustments for achieving immunosuppression based on the CYP3A5 diplotypes compared to other world populations. Distinct distribution of actionable pharmacogenomic variation was also observed among the Qatari subpopulations. Our comprehensive study of the distribution of actionable genetic variation affecting drugs in a Middle Eastern population has potential implications for preemptive pharmacogenomic implementation in the region and beyond. 2022, The Author(s).
راعي المشروعPVJ is supported by faculty funding from the College of Health & Life Sciences, HBKU. Qatar Biobank and Qatar Genome Program are Research, Development & Innovation's entities within Qatar Foundation for Education, Science and Community Development. Funders had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
اللغةen
الناشرNature Research
الموضوعPersonalized medicine
Pharmacogenomics
العنوانA population study of clinically actionable genetic variation affecting drug response from the Middle East
النوعArticle
رقم العدد1
رقم المجلد7


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