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AuthorElgendy, Hamed M
AuthorIbrahim, Sami M
AuthorBader, Loulia
AuthorMohammad, Rudaina A
AuthorAli, Zainab O
AuthorBejaoui, Mohamed Ben Allala
AuthorHilani, Mohamad
AuthorIsmail, Hesham
AuthorElewa, Hazem F
Available date2023-08-29T06:52:24Z
Publication Date2023
Publication NameJournal of Pain Research
Identifierhttp://dx.doi.org/10.2147/JPR.S420447
CitationElgendy HM, Ibrahim SM, Bader L, Mohammad RA, Ali ZO, Bejaoui MBA, Hilani M, Ismail H, Elewa HF. Genetic Factors Associated with Morphine Consumption in Women Undergoing Laparoscopic Cholecystectomy: A Prospective Cohort Study. J Pain Res. 2023;16:2407-2417 https://doi.org/10.2147/JPR.S420447
ISSN1178-7090
URIhttp://hdl.handle.net/10576/46958
AbstractMorphine has been a crucial analgesic agent used perioperatively in various surgical procedures. Genetic factors can lead to morphine dose requirement interpatient variability. Our objective was to determine the contribution of genetic polymorphisms in human μ-opioid receptor gene (OPRM1), ATP binding cassette gene (ABCB1) and rs2952768 to the variation of the perioperative morphine consumption in women undergoing laparoscopic cholecystectomy. This is a prospective cohort study that included 102 adult Arab females undergoing laparoscopic cholecystectomy. The exposures were carrying the genetic variants of and rs2952768. Our primary outcome was total morphine or morphine equivalent dose required perioperatively. The secondary outcomes were pain score during the first 24 hours and adverse drug reactions. A standardized, general anaesthesia was used for all subjects. In addition to the genetic factors, we also investigated non-genetic factors influencing post-operative pain sensitivity and morphine consumption. Both (rs1799971, A>G) in and (rs2952768, T>C) showed statistically significant association with intra-operative total morphine dose requirements. Patients carrying the "G" allele in had a significantly higher total morphine mean rank dose compared to the AA genotype [62.9 vs 47.1, =0.008]. Furthermore, patients homozygous for the rs2952768 (T>C) minor allele "CC" had a higher mean rank compared to the other genotypes [72.7 vs 50.1, =0.046]. (rs1799971) and rs2952768 are associated with variation of intra-operative morphine consumption in laparoscopic cholecystectomy. This study was registered at ClinicalTrials.gov, NCT04621864. https://clinicaltrials.gov/ct2/show/NCT04621864.
Languageen
PublisherDove Press Ltd
SubjectABCB1
Arabs
OPRM1
genetic polymorphisms
opioid
post-operative pain
women
TitleGenetic Factors Associated with Morphine Consumption in Women Undergoing Laparoscopic Cholecystectomy: A Prospective Cohort Study.
TypeArticle
Pagination2407-2417
Volume Number16
dc.accessType Open Access


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