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AuthorEjaj, Ahmad
AuthorAli, Asgar
AuthorFatima, Munazza Tamkeen
AuthorNimisha
AuthorApurva
AuthorKumar, Arun
AuthorSumi, Mamta P.
AuthorSattar, Real Sumayya Abdul
AuthorMahajan, Bhawna
AuthorSaluja, Sundeep Singh
Available date2023-09-05T08:39:25Z
Publication Date2021-05-31
Publication NamePharmacological Research
Identifierhttp://dx.doi.org/10.1016/j.phrs.2021.105544
CitationAhmad, E., Ali, A., Fatima, M. T., Kumar, A., Sumi, M. P., Sattar, R. S. A., ... & Saluja, S. S. (2021). Ligand decorated biodegradable nanomedicine in the treatment of cancer. Pharmacological Research, 167, 105544.‏
ISSN10436618
URIhttps://www.sciencedirect.com/science/article/pii/S1043661821001286
URIhttp://hdl.handle.net/10576/47237
AbstractCancer is one of the major global health problems, responsible for the second-highest number of deaths. The genetic and epigenetic changes in the oncogenes or tumor suppressor genes alter the regulatory pathways leading to its onset and progression. Conventional methods are used in appropriate combinations for the treatment. Surgery effectively treats localized tumors; however, it fails to treat metastatic tumors, leading to a spread in other organs, causing a high recurrence rate and death. Among the different strategies, the nanocarriers-based approach is highly sought for, but its nonspecific delivery can cause a profound side effect on healthy cells. Targeted nanomedicine has the advantage of targeting cancer cells specifically by interacting with the receptors overexpressed on their surface, overcoming its non-specificity to target healthy cells. Nanocarriers prepared from biodegradable and biocompatible materials are decorated with different ligands by encapsulating therapeutic or diagnostic agents or both to target cancer cells overexpressing the receptors. Scientists are now utilizing a theranostic approach to simultaneously evaluate nanocarrier bio-distribution and its effect on the treatment regime. Herein, we have summarized the recent 5-year efforts in the development of the ligands decorated biodegradable nanocarriers, as a targeted nanomedicine approach, which has been highly promising in the treatment of cancer.
Languageen
PublisherElsevier
SubjectHyaluronic Acid
Biodegradable nanocarriers
Transferrin
Phospholipids
CD44
TitleLigand decorated biodegradable nanomedicine in the treatment of cancer
TypeArticle
Volume Number167
dc.accessType Abstract Only


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