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    UPLC-HRESI-MS and GC-MS analysis of the leaves of Nicotiana glauca

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    10.2478_acph-2022-0001.pdf (1.390Mb)
    Date
    2022
    Author
    Massadeh, R.K.
    El-Elimat, T.
    Al-Gharaibeh, M.
    Tawaha, K.
    Alali, F.Q.
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    Abstract
    The alkaloid-rich fraction obtained by fractionation of the crude methanolic extract of the leaves of wild tobacco tree Nicotiana glauca Graham (Solanaceae) was analyzed using UPLC-MS and GC-MS. Anabasine, a piperidine alkaloid, was identified as the major constituent with approximately 60 % (m/m) of the alkaloid-rich fraction. In addition to anabasine, six secondary metabolites were identified using high-resolution UPLC-MS. Anabasine was quantified in the leaves to be 1 mg g-1 dry plant material. The GC-MS analysis revealed five compounds with anabasine as the major component, while nicotine was not detected. Moreover, GC-MS was used for the analysis of the volatile oil that was obtained by hydro-distillation from the leaves of N. glauca. The volatile plant oil was found to be rich in oxygenated sesquiterpenes (e.g., ?-bisabolol) and carboxylic acids and esters (e.g., ethyl linoleate and hexadecanoic acid), whereas anabasine was not detected.
    DOI/handle
    http://dx.doi.org/10.2478/acph-2022-0001
    http://hdl.handle.net/10576/47637
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    • Pharmacy Research [‎1389‎ items ]

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