Show simple item record

AuthorSayed, Tahseen S.
AuthorMaayah, Zaid H.
AuthorZeidan, Heba A.
AuthorAgouni, Abdelali
AuthorKorashy, Hesham M.
Available date2023-09-20T08:47:08Z
Publication Date2022
Publication NameCellular and Molecular Biology Letters
ResourceScopus
ISSN14258153
URIhttp://dx.doi.org/10.1186/s11658-022-00397-7
URIhttp://hdl.handle.net/10576/47773
AbstractThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates the toxicities of several environmental pollutants. Decades of research have been carried out to understand the role of AhR as a novel mechanism for disease development. Its involvement in the pathogenesis of cancer, cardiovascular diseases, rheumatoid arthritis, and systemic lupus erythematosus have long been known. One of the current hot research topics is investigating the role of AhR activation by environmental pollutants on glucose homeostasis and insulin secretion, and hence the pathogenesis of diabetes mellitus. To date, epidemiological studies have suggested that persistent exposure to environmental contaminants such as dioxins, with subsequent AhR activation increases the risk of specific comorbidities such as obesity and diabetes. The importance of AhR signaling in various molecular pathways highlights that the role of this receptor is far beyond just xenobiotic metabolism. The present review aims at providing significant insight into the physiological and pathological role of AhR and its regulated enzymes, such as cytochrome P450 1A1 (CYP1A1) and CYP1B1 in both types of diabetes. It also provides a comprehensive summary of the current findings of recent research studies investigating the role of the AhR/CYP1A1 pathway in insulin secretion and glucose hemostasis in the pancreas, liver, and adipose tissues. This review further highlights the molecular mechanisms involved, such as gluconeogenesis, hypoxia-inducible factor (HIF), oxidative stress, and inflammation.
SponsorThis publication was supported by Qatar University Internal Grant no. IRCC-2022-484, Doha, Qatar.
Languageen
PublisherBioMed Central Ltd
SubjectAryl hydrocarbon receptor
Diabetes mellitus
Environmental toxicants
Glucose hemostasis
Insulin
TitleInsight into the physiological and pathological roles of the aryl hydrocarbon receptor pathway in glucose homeostasis, insulin resistance, and diabetes development
TypeArticle Review
Issue Number1
Volume Number27
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record