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AuthorElmekaty, Eman Zeyad I.
AuthorAlibrahim, Rim
AuthorHassanin, Rania
AuthorEltaib, Sitelbanat
AuthorElsayed, Ahmed
AuthorRustom, Fatima
AuthorIbrahim, Mohamed Izham Mohamed
AuthorKhattab, Mohammed Abu
AuthorAl Soub, Hussam
AuthorAl Maslamani, Muna
AuthorAl-Khal, Abdullatif
Available date2023-09-20T08:47:09Z
Publication Date2022
Publication NamePLoS ONE
ResourceScopus
ISSN19326203
URIhttp://dx.doi.org/10.1371/journal.pone.0267884
URIhttp://hdl.handle.net/10576/47780
AbstractBackground Coronavirus Disease 2019 (COVID-19) is an evolving pandemic that urged the need to investigate various antiviral therapies. This study was conducted to compare efficacy and safety outcomes of darunavir-cobicistat versus lopinavir-ritonavir in treating patients with COVID-19 pneumonia. Methods and findings This retrospective, multicenter, observational study was conducted on adult patients hospitalized in one of the COVID-19 facilities in Qatar. Patients were included if they received darunavir-cobicistat or lopinavir-ritonavir for at least three days as part of their COVID-19 treatments. Data were collected from patients' electronic medical records. The primary outcome was a composite endpoint of time to clinical improvement and/or virological clearance. Descriptive and inferential statistics were used at alpha level of 0.05. A total of 400 patients was analyzed, of whom 100 received darunavir-cobicistat and 300 received lopinavir-ritonavir. Majority of patients were male (92.5%), with a mean (SD) time from symptoms onset to start of therapy of 7.57 days (4.89). Patients received lopinavir-ritonavir had significantly faster time to clinical improvement and/or virological clearance than patients received darunavir-cobicistat (4 days [IQR 3-7] vs. 6.5 days [IQR 4-12]; HR 1.345 [95%CI: 1.070-1.691], P = 0.011). Patients received lopinavir-ritonavir had significantly faster time to clinical improvement (5 days [IQR 3-8] vs. 8 days [IQR 4-13]; HR 1.520 (95%CI: 1.2-1.925), P = 0.000), and slower time to virological clearance than darunavir-cobicistat (25 days [IQR 15-33] vs. 21 days [IQR 12.8-30]; HR 0.772 (95%CI: 0.607-0.982), P = 0.035). No significant difference in the incidence or severity of adverse events between groups. The study was limited to its retrospective nature and the possibility of covariates, which was accounted for by multivariate analyses. Conclusion In patients with COVID-19 pneumonia, early treatment with lopinavir-ritonavir was associated with faster time to clinical improvement and/or virological clearance than darunavir-cobicistat. Future trials are warranted to confirm these findings.
Languageen
PublisherPublic Library of Science
SubjectAnti Human Immunodeficiency Virus Agent
Rilpivirine
Cobicistat
TitleDarunavir-cobicistat versus lopinavir-ritonavir in the treatment of COVID-19 infection (DOLCI): A multicenter observational study
TypeArticle
Issue Number5-May
Volume Number17
dc.accessType Open Access


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