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AuthorAllahverdi, Niloofar
AuthorYassin, Mohamed
AuthorIbrahim, Mohamed
Available date2023-09-20T08:47:10Z
Publication Date2021
Publication NameCancer Control
ResourceScopus
ISSN10732748
URIhttp://dx.doi.org/10.1177/10732748211046802
URIhttp://hdl.handle.net/10576/47791
AbstractMyeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the overproduction of mature myeloid cells and are often associated with an acquired genetic mutation of Janus Kinase2V617F. Various epidemiological studies have indicated associations between environmental factors, lifestyle factors, and host characteristics with developing MPNs. This review aims to collect and summarize the existing information on these risk factors and establish their association with pathogenesis MPNs. Medline, Embase, PubMed, and grey literature were systematically searched using key terms for MPNs, and epidemiological study designs, that is, cross-sectional studies, case-control, and cohort, that investigated the risk factors for MPNs published were identified. Out of the 4621 articles identified, 20 met the selection criteria and were included in this review. Heterogeneity, study reliability, and bias were assessed. A significant association was found between smoking and the development of MPNs. This relationship has been explained by the substantial increase in several proinflammatory mediators and systematic oxidative stress causing hyperstimulation of myeloid compartments leading to the development of MPNs. Obesity was modestly linked with an increased risk of MPNs. The underlying mechanisms have been linked to changes in endocrine, metabolic, and inflammatory systems. No strong association was found between exposure to hazardous substances, that is, benzene and MPNs, but further investigation on the effects of increased levels and duration of exposure on hematopoietic stem cells will be beneficial. Unique individual and host variations have been determined as a modifier of disease pathogenesis and phenotype variations. There is a higher incidence rate of females developing MPNs, specifically ET, than males with higher PV incidence. Therefore, gender contributes to the heterogeneity in myeloproliferative neoplasm. Studies identified as part of this review are very diverse. Thus, further in-depth assessment to explore the role of these etiological factors associated with MPNs is warranted.
SponsorThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study is supported by Qatar University Student Grant (QUST-2-CPH-2020-12)
Languageen
PublisherSAGE Publications Ltd
Subjectbenzene
environmental
essential thrombocythemia
gender
host characteristics
lifestyle
myeloproliferative disease
myeloproliferative neoplasm
obesity
polycythemia vera
primary myelofibrosis
risk factor
smoking
TitleEnvironmental Factors, Lifestyle Risk Factors, and Host Characteristics Associated With Philadelphia Negative Myeloproliferative Neoplasm: A Systematic Review
TypeArticle Review
Volume Number28
dc.accessType Open Access


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