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AuthorSherman, Elizabeth M.
AuthorNiu, Jianli
AuthorElrod, Shara
AuthorClauson, Kevin A.
AuthorAlkhateeb, Fadi
AuthorEckardt, Paula
Available date2023-09-20T08:47:11Z
Publication Date2020
Publication NameAIDS Research and Therapy
ResourceScopus
ISSN17426405
URIhttp://dx.doi.org/10.1186/s12981-020-00275-2
URIhttp://hdl.handle.net/10576/47799
AbstractBackground People with HIV (PHIV) with limited access to health services often experience suboptimal antiretroviral therapy (ART) adherence. We investigated whether a daily text messaging intervention improves ART adherence and retention in early HIV care in PHIV in a south Florida hospital-based clinic. Methods ART-naïve PHIV receiving care through the clinic’s Ryan White HIV/AIDS Program were enrolled and randomly assigned to the intervention or control groups with a 1:1 ratio. The intervention group received a 1-way text message daily and the control group received standard care without receiving text message reminders for 6 months. HIV RNA and CD4 cell count were measured at baseline and post-intervention. Adherence to ART was defined as a visual analog scale of ≥ 90%. Retention in care was defined as continued engagement at study end. Results 94 ART-naïve patients were randomized and 83 (85.6%) completed the study, of which 44 were in the intervention group and 39 were in the control group. At the end of the 6-month study period, adherence to ART was 84.4% in the intervention group versus 73.5% in the control group (OR, 1.9; 95% CI 0.7–5.0; p = 0.194). Retention in care significantly improved in the intervention group compared to the control group with the odds of retention increasing by 20% (OR, 1.2; 95% CI 1.1–1.5; p = 0.006). Undetectable HIV RNA (< 50 copies/mL) was 86.7% in the intervention group versus 73.5% in the control group (OR, 2.3; 95% CI 0.8–6.9; p = 0.112). A significant increase in CD4 cell count and a decrease in HIV RNA were found at study end, with no differences between the two groups. Conclusions In this pilot study, a one-way daily text messaging intervention did not improve ART adherence over a 6-month study period, but significantly enhanced patient retention in early HIV care. Implementation of interventions to improve adherence in this population is required.
SponsorThis work was supported by the Nova Southeastern University Health Professions Division Research Grant and the Nova Southeastern University President's Faculty Research and Development Grant.
Languageen
PublisherBioMed Central Ltd.
SubjectHIV
Medication adherence
Mobile health
SMS
Text message
TitleEffect of mobile text messages on antiretroviral medication adherence and patient retention in early HIV care: An open-label, randomized, single center study in south Florida
TypeArticle
Issue Number1
Volume Number17


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