Associations of Vitamin D Receptor Polymorphisms with Coronary Artery Diseases

Abstract

Background: Previous studies have investigated the association of rs1544410, rs7975232 and rs731236 polymorphisms on vitamin D receptor gene and its impact on diseases such as cancer, diabetes and hypertension in different ethnic backgrounds.

Aim: The aim of this study is to investigate the association between VDR polymorphisms using three SNP’s and the severity of the significant lesion in coronary arteries among angiographically diagnosed CAD .

Methods: 192 CAD patients enrolled from the cardiology department-Heart Hospital, Hammed Medical Corporation (HMC). Medical records, biochemical tests data and DNA samples were obtained from a previous study conducted in 2012.

Results: By studying SNP rs7975232 it has been observed that the most frequent genotype in distribution is the AA among the significant stenosis patients, while the heterozygous AC was the frequent genotype in distribution among the non-significant stenosis group.

Conclusion: There is a significant association between rs7975232 and the severity of CAD lesion. The carrier of CC genotype in rs7975232 increased the risk of having significant coronary arteries atherosclerotic lesion especially in patients with smoking history.