Biomedical Sciences: المرسلات الحديثة
السجلات المعروضة 1 -- 20 من 756
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Association between clinical laboratory indicators and WOMAC scores in Qatar Biobank participants: The impact of testosterone and fibrinogen on pain, stiffness, and functional limitation
( Walter de Gruyter GmbH , 2025 , Article)Objectives: The association between baseline laboratory parameters and experienced well-being in healthy individuals remains uncertain. This study explored the relationship between clinical laboratory profiles and Western ... -
Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic Potential
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence "GATA", which ... -
Metformin-loaded nanoparticles reduce hyperglycemia-associated oxidative stress and induce eNOS phosphorylation in vascular endothelial cells
( Nature Research , 2024 , Article)Diabetes mellitus is a chronic disease characterized by metabolic defects, including insulin deficiency and resistance. Individuals with diabetes are at increased risk of developing cardiovascular complications, such as ... -
Metabarcoding analysis of oral microbiome during pregnancy
( Frontiers Media SA , 2024 , Article)Pregnancy is a dynamic physiological process involving significant hormonal, immune, and metabolic changes to support fetal growth and development. This study investigates the changes in salivary microbiome and biochemical ... -
Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population
( Springer , 2024 , Article)Speckle-type POZ (SPOP) is described as an essential tumor suppressor factor in gastric cancer, colorectal cancer, and prostate cancer (PCa). SPOP gene mutations were reported in primary human PCa. Isocitrate dehydrogenase-1 ... -
GATA3: Orchestrating cellular fate through differentiation and proliferation
( Elsevier , 2025 , Article Review)Cell proliferation and differentiation are two fundamental biological processes that occur in biological systems, tightly regulated by various factors such as transcription factors (TFs). Zinc finger proteins are TFs ... -
Mindray CL-900i assay: An effective assay for hepatitis B surface antigen screening with superior specificity
( Elsevier , 2025 , Article)Objectives The chemiluminescence immunoassay automated Abbott ARCHITECT hepatitis B surface antigen (HBsAg) screening assay is globally recognized for its superior sensitivity but notably low specificity. This mandates ... -
Molecular identification and characterization of waterborne protozoa among stranded Dugong dugon
( Elsevier , 2025 , Article)The Persian Gulf hosts the second-largest population of Dugongs. The International Union for the Conservation of Nature (IUCN) lists them as Vulnerable to Extinction species. Incidental fishing, vessel strikes, environmental ... -
Chapter Seven Exploring the effect of disease causing mutations in metal binding sites of human ARSA in metachromatic leukodystrophy
( Elsevier , 2024 , Book chapter)The arylsulfatase A (ARSA) gene is observed to be deficient in patients with metachromatic leukodystrophy (MLD), a type of lysosomal storage disease. MLD is a severe neurodegenerative disorder characterized by an autosomal ... -
Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar
( Elsevier , 2025 , Article)Breast cancer is a global health concern, including in Qatar, where it impacts women significantly. The complexity of breast cancer requires diverse treatment approaches influenced by tumor characteristics and biology. ... -
Advances in Huntington’s Disease Biomarkers: A 10-Year Bibliometric Analysis and a Comprehensive Review
( MDPI , 2025 , Article Review)Neurodegenerative disorders (NDs) cause progressive neuronal loss and are a significant public health concern, with NDs projected to become the second leading global cause of death within two decades. Huntington’s disease ... -
Universal Genetic Testing for Newly Diagnosed Invasive Breast Cancer
( American Medical Association , 2024 , Article)IMPORTANCE Between 5% and 10% of breast cancer cases are associated with an inherited germline pathogenic or likely pathogenic variant (GPV) in a breast cancer susceptibility gene (BCSG), which could alter local and systemic ... -
In vivo assessment of the nephrotoxic effects of the synthetic cannabinoid AB-FUBINACA
( Springer , 2024 , Article)Background: The widespread misuse of synthetic cannabinoids (SCs) has led to a notable increase in reported adverse effects, raising significant health concerns. SCs use has been particularly associated with acute kidney ... -
The dynamic role of immune checkpoint molecules in diagnosis, prognosis, and treatment of head and neck cancers
( Elsevier , 2024 , Article Review)Head and neck cancer (HNC) is the sixth most common cancer type, accounting for approximately 277,597 deaths worldwide. Recently, the Food and Drug Administration (FDA) has approved immune checkpoint blockade (ICB) agents ... -
Pathogenic mechanisms, diagnostic, and therapeutic potential of microvesicles in diabetes and its complications
( Elsevier , 2024 , Article Review)Extracellular vesicles (EVs), particularly microvesicles (MVs), have gained significant attention for their role as mediators of intercellular communication in both physiological and pathological contexts, including diabetes ... -
Exploring the Impact of Cigarette Smoke Extracts on Vitamin B12: Insights into the Transformation of Methylcobalamin and Hydroxycobalamin to Cyanocobalamin through in Vitro Evaluation
( John Wiley and Sons , 2024 , Article)Vitamin B12 (cobalamin) is a water-soluble molecule required for the proper functioning of metabolism, blood and DNA synthesis, and neurological development. Vitamin B12 exists in several forms: methylcobalamin (MeCbl), ... -
Pharmacometabolomics of sulfonylureas in patients with type 2 diabetes: a cross-sectional study
( Frontiers Media SA , 2024 , Article)Background: Sulfonylureas have been a longstanding pharmacotherapy in the management of type 2 diabetes, with potential benefits beyond glycemic control. Although sulfonylureas are effective, interindividual variability ... -
Unraveling the effect of molecular medium on the fluorosolvatochromism of the biphenyl- salicylate derivative drug Diflunisal: Experimental and computational study
( Elsevier , 2024 , Article)Understanding the photochemical behavior of a photosensitive drug through its molecular properties is crucial for assessing potential phototoxicity. In this study, we examine how the molecular microenvironment influences ... -
Maternal and neonatal risks and outcomes after bariatric surgery: a comparative population based study across BMI categories in Qatar.
( Springer Nature , 2024 , Article)The impact of Bariatric Surgery (BS) on maternal and neonatal outcomes among pregnant women is not fully understood, especially in comparison to different weight categories. The primary aim of this study is to assess the ... -
Identification of KSR2 Variants in Pediatric Patients with Severe Early-Onset Obesity from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The kinase suppressor of Ras 2 (KSR2) gene is associated with monogenic obesity, and loss-of-function variants in KSR2 have been identified in individuals with severe early-onset obesity. This study investigated KSR2 ...
