Biomedical Sciences: المرسلات الحديثة
السجلات المعروضة 81 -- 100 من 711
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Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance (Molecular Cancer, (2020), 19, 1, (57), 10.1186/s12943-020-01175-9)
( BMC , 2020 , Other)Following the publication of the original article [1], authors have noticed that one of the authors, Syed Shadab Raza, was missing in the Authors’ Contributions section. Please see below updated section. -
Forging the Path to Precision Medicine in Qatar: A Public Health Perspective on Pharmacogenomics Initiatives
( Frontiers Media , 2024 , Article Review)Pharmacogenomics (PGx) is an important component of precision medicine that promises tailored treatment approaches based on an individual’s genetic information. Exploring the initiatives in research that help to integrate ... -
The role of genetic and epigenetic GNAS alterations in the development of early-onset obesity
( Elsevier , 2023 , Article)BackgroundGNAS (guanine nucleotide-binding protein, alpha stimulating) is an imprinted gene that encodes Gsα, the α subunit of the heterotrimeric stimulatory G protein. This subunit mediates the signalling of a diverse ... -
Mangifera indica L. kernel ethanol extract inhibits cell viability and proliferation with induction of cell cycle arrest and apoptosis in lung cancer cells
( Taylor and Francis Ltd. , 2024 , Article)In this study, we investigated the effects of an ethanolic extract of Mangifera indica L. kernel on the viability and proliferation of human lung cancer cells. We utilized MTT and BrdU cell proliferation assays, morphological ... -
Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach
( IMR Press Limited , 2023 , Article)Background: Mutations in the K-Ras gene are among the most frequent genetic alterations in various cancers, and inhibiting RAS signaling has shown promising results in treating solid tumors. However, finding effective drugs ... -
Rational design of a multivalent vaccine targeting arthropod-borne viruses using reverse vaccinology strategies
( Elsevier , 2024 , Article)Viruses transmitted by arthropods, such as Dengue, Zika, and Chikungunya, represent substantial worldwide health threats, particularly in countries like India. The lack of approved vaccines and effective antiviral therapies ... -
Genomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
( Springer , 2024 , Article)Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and function. In this study, we employed advanced bioinformatics and explainable AI to analyze gene ... -
Congenital absence of appendix: a rare condition that could result in severe complications-a review of literature
( Oxford University Press , 2023 , Article)Acute appendicitis is the most frequent cause of abdominal pain and acute emergency surgeries, with a mortality risk of 6-7% at its onset. Since atypical deviations in these structures are rare, they can lead to diagnosis ... -
Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)The leptin–melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The MC4R gene plays a central role in ... -
Exploring Emotional Intelligence and Sociodemographics in Higher Education; the Imperative for Skills and Curriculum Development
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)There is increasing interest in understanding the nature and impact of emotional intelligence (EI) in educational institutions and the workplace since EI is associated with academic performance, career success, job ... -
Estimating protection afforded by prior infection in preventing reinfection: Applying the test-negative study design.
( Oxford University Press , 2023 , Article)The COVID-19 pandemic has highlighted the need to use infection testing databases to rapidly estimate effectiveness of prior infection in preventing reinfection ($P{E}_S$) by novel SARS-CoV-2 variants. Mathematical modeling ... -
Laparoscopic management of intestinal obstruction in a young adult with a virgin abdomen: Unusual presentation of combined vitellointestinal duct remnants: A clinical case report.
( Wiley Open Access , 2024 , Article)In an 18-year-old, Meckel's diverticulum and a rare vitellointestinal fibrous band caused bowel obstruction. Clinicians should be vigilant for such anomalies, especially in young adults with virgin abdomens, as potential ... -
Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells.
( Bentham Science Publishers , 2024 , Article)Cell culture plays a crucial role in addressing fundamental research questions, particularly in studying insulin resistance (IR) mechanisms. Multiple in vitro models are utilized for this purpose, but their technical ... -
Investigating Inflammatory Markers in Wound Healing: Understanding Implications and Identifying Artifacts
( American Chemical Society (ACS) , 2024 , Article)Understanding the complex interplay of pro-inflammatory and anti-inflammatory cytokines is crucial in the field of wound healing, as it holds the key to developing effective therapeutics. In the initial stages of wound ... -
Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality
( Springer Nature , 2024 , Article)Lead is a heavy, toxic metal and its exposure to humans can lead to increased risk of cardiovascular disease development and mortality. Lead exposure has been shown to induce hyperhomocysteinemia (HHCy) which may be a major ... -
The synthetic cannabinoids menace: a review of health risks and toxicity
( Springer Nature , 2024 , Article)Synthetic cannabinoids (SCs) are chemically classified as psychoactive substances that target the endocannabinoid system in many body organs. SCs can initiate pathophysiological changes in many tissues which can be severe ... -
Imaging Patterns in Breast Cancer for Women Under 40 Years: A Descriptive Cohort Study
( Springer Nature , 2024 , Article)Background and Aim: Breast cancer is the most frequently occurring malignant disease in women and remains the leading cause of cancer-related deaths among females worldwide. The aim of this study is to evaluate the imaging ... -
Determination of Medicago orbicularis Antioxidant, Antihemolytic, and Anti-Cancerous Activities and Its Augmentation of Cisplatin-Induced Cytotoxicity in A549 Lung Cancer Cells
( MDPI , 2023 , Article)The anti-lung cancer properties of the plant Medicago orbicularis have not been explored yet. Therefore, we identified its phytochemical composition and investigated the antioxidant, anti-hemolytic, and anti-cancerous ... -
Psychosocial impact of COVID-19 pandemic: experience of healthcare workers in Qatar
( Frontiers Media SA , 2023 , Article)Background: The COVID-19 pandemic has had a profound and global impact on healthcare systems worldwide, presenting unprecedented challenges for healthcare workers (HCWs) on the front. We aimed to evaluate the prevalence ... -
Single-cell transcriptomic analysis reveals crucial oncogenic signatures and its associative cell types involved in gastric cancer
( Springer Nature , 2023 , Article)The intricate association of oncogenic markers negatively impacts accurate gastric cancer diagnosis and leads to the proliferation of mortality rate. Molecular heterogeneity is inevitable in determining gastric cancer's ...