Biomedical Sciences: Recent submissions
Now showing items 41-60 of 711
-
Total and high molecular weight adiponectin in patients with coronary artery disease
( Wolters Kluwer Health , 2009 , Article)BACKGROUND: Serum adiponectin inversely correlates with the extent of coronary artery disease (CAD). OBJECTIVES: To investigate the clinical significance of measuring high molecular weight (HMW) adiponectin in addition to ... -
A pilot study on metabolic syndrome and its associated features among Qatari schoolchildren
( Dove Medical Press , 2011 , Article)Aim: This pilot study aimed to evaluate the individual features of the metabolic syndrome (MeS) and its frequency in Qatari schoolchildren aged 6-12 years. Background: MeS has a strong future risk for development of diabetes ... -
Interleukin-28 and hepatitis C virus genotype-4: Treatmentinduced clearance and liver fibrosis
( Baishideng Publishing Group , 2012 , Article)AIM: To investigate the association between interleukin-28B (IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus (HCV) genotype 4. METHODS: Two hundred and one HCV-genotype 4 ... -
Addressing bias in the definition of SARS-CoV-2 reinfection: implications for underestimation
( Frontiers Media , 2024 , Article)Introduction: Reinfections are increasingly becoming a feature in the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, accurately defining reinfection poses methodological ... -
Antibody-dependent enhancement (ADE) of SARS-CoV-2 in patients exposed to MERS-CoV and SARS-CoV-2 antigens
( Wiley , 2024 , Article)This study evaluated the potential for antibody-dependent enhancement (ADE) in serum samples from patients exposed to Middle East respiratory syndrome coronavirus (MERS-CoV). Furthermore, we evaluated the effect of severe ... -
Elevated serum leptin levels in patients with acute myocardial infarction; Correlation with coronary angiographic and echocardiographic findings
( Springer Nature , 2012 , Article)Background: To assess the relationship between serial serum leptin levels in patients with acute myocardial infarction (AMI) who received thrombolysis and the degree of coronary atherosclerosis, coronary reperfusion, ... -
Prevalence of hepatitis B and C viruses among migrant workers in Qatar.
( Springer Nature , 2024 , Article)Limited data exist on viral hepatitis among migrant populations. This study investigated the prevalence of current hepatitis B virus (HBV) infection and lifetime hepatitis C virus (HCV) infection among Qatar's migrant craft ... -
Quantitative metabolomic and lipidomic profiling reveals aberrant amino acid metabolism in type 2 diabetes
( Royal Society of Chemistry , 2013 , Article)Type 2 diabetes (T2DM) is a multi-factorial disease with a complex pathogenic mechanism; however a complete understanding of precise biochemical alterations accompanying the onset and progression of T2DM is lacking. Using ... -
Significant association of close homologue of L1 gene polymorphism rs2272522 with schizophrenia in Qatar
( Wiley Online Library , 2012 , Article)Introduction: Previous reports have found that polymorphisms in the close homologue of L1 (CHL1) gene located on chromosome 3p26 are associated with schizophrenia among different ethnic populations. The aim of this study ... -
Association of adiponectin gene polymorphism (+T45G) with acute coronary syndrome and circulating adiponectin levels
( SAGE , 2012 , Article)We investigated the association of adiponectin gene polymorphisms (+T45G and +G276T) and adiponectin levels with acute coronary syndrome (ACS) among Arabs in Qatar. A case-control study was performed in 142 Arab patients ... -
Genetic polymorphisms of ICAM 1 and IL28 as predictors of liver fibrosis severity and viral clearance in hepatitis C genotype 4
( Elsevier , 2013 , Article)Background and objectivesIntercellular adhesion molecule-1 (ICAM-1) is located on chromosome 19p13.2, and this protein plays an important role in the pathogenesis of the hepatitis C virus (HCV). The rs12979860 polymorphism ... -
The predictive value of IL28B rs12979860, rs11881222 and rs8099917 polymorphisms and IP-10 in the therapeutic response of Egyptian genotype 4 patients
( Elsevier , 2013 , Article)Interleukin-28B (IL28B) polymorphisms have previously been reported to be strongly associated with spontaneous and treatment-induced HCV viral clearance. AimTo assess the impact of four different IL28B polymorphisms and ... -
Exploring the role of oral microbiome dysbiosis in cardiometabolic syndrome and smoking
( Taylor and Francis Ltd. , 2024 , Article Review)Oral microbiome research has gained significant interest in recent years due to its potential impact on overall health. Smoking has been identified as a significant modulator of the oral microbiome composition, leading to ... -
Efficacy and Clinical Outcomes of mRNA COVID-19 Vaccine in Pregnancy: A Systematic Review and Meta-Analysis
( S. Karger AG , 2024 , Article)BACKGROUND: The world has witnessed one of the largest pandemics, dubbed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of December 2020, the USA alone reported 98,948 cases of coronavirus disease 2019 ... -
Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats
( Elsevier , 2024 , Article)Esculeoside A (ESA) is a tomato-derived glycoside with antioxidant and anti-inflammatory properties. The protective effect of ESA against diabetic retinopathy is not well-investigated and was the core objective of this ... -
Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria
( Portland Press Ltd , 2024 , Article)Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 50-phosphate (PLP)-dependent enzyme in the transsulfuration ... -
microRNA 21 and long non-coding RNAs interplays underlie cancer pathophysiology: A narrative review
( Elsevier , 2024 , Article)Non-coding RNAs (ncRNAs) are a diverse group of functional RNA molecules that lack the ability to code for proteins. Despite missing this traditional role, ncRNAs have emerged as crucial regulators of various biological ... -
The impact of chronic fentanyl administration on the cerebral cortex in mice: Molecular and histological effects
( Elsevier , 2024 , Article)Purpose: Fentanyl, a fully synthetic opioid, is widely used for severe pain management and has a huge abuse potential for its psychostimulant effects. Unlike other opioids, the neurotoxic effects of chronic fentanyl ... -
Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
( BMC , 2024 , Article)The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ... -
Vitamin B12 deficiency in diabetic patients treated with metformin: A narrative review
(2024 , Article)Metformin is the most prescribed oral hypoglycemic drug and is considered by many health practitioners as the first-line treatment for non-insulin-dependent diabetes mellitus (T2DM). It is used either as a monotherapy or ...