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AuthorSharma, Tarang
AuthorGupta, Ashna
AuthorChauhan, Ravi
AuthorBhat, Ajaz A.
AuthorNisar, Sabah
AuthorHashem, Sheema
AuthorAkhtar, Sabah
AuthorAhmad, Aamir
AuthorHaris, Mohammad
AuthorSingh, Mayank
AuthorUddin, Shahab
Available date2023-10-30T05:33:40Z
Publication Date2022-06-01
Publication NameCancer and Metastasis Reviews
Identifierhttp://dx.doi.org/10.1007/s10555-022-10026-6
CitationSharma, T., Gupta, A., Chauhan, R. et al. Cross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis. Cancer Metastasis Rev 41, 281–299 (2022). https://doi.org/10.1007/s10555-022-10026-6
ISSN01677659
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129452267&origin=inward
URIhttp://hdl.handle.net/10576/48860
AbstractEsophageal cancer (EC) is frequently considered a lethal malignancy and is often identified at a later stage. It is one of the major causes of cancer-related deaths globally. The conventional treatment methods like chemotherapy, radiotherapy, and surgery offer limited efficacy and poor clinical outcome with a less than 25% 5-year survival rate. The poor prognosis of EC persists despite the growth in the development of diagnostic and therapeutic modalities to treat EC. This underlines the need to elucidate the complex molecular mechanisms that drive esophageal oncogenesis. Apart from the role of the tumor microenvironment and its structural and cellular components in tumorigenesis, mounting evidence points towards the involvement of the esophageal microbiome, inflammation, and their cross-talk in promoting esophageal cancer. The current review summarizes recent research that delineates the underlying molecular mechanisms by which the microbiota and inflammation promote the pathophysiology of esophageal cancer, thus unraveling targets for potential therapeutic intervention.
SponsorOpen Access funding provided by the Qatar National Library. This study was supported by Medical Research Center grant no #16354/16, Hamad Medical Corporation, Doha Qatar to SU while AIIMS Intramural grant (Grant number: A514) and AIIMS IITD Grant (AI-34) from All India Institute of Medical Sciences (AIIMS) New Delhi, Delhi India to MS. This study was funded, in part, by Sidra Medicine Precision Program (Ajaz A. Bhat [5081012003] and Mohammad Haris [5081012002]. Open Access funding is provided by Qatar National Library, Doha, Qatar.
Languageen
PublisherSpringer
SubjectEsophageal adenocarcinoma
Esophageal squamous cell carcinoma
Inflammation, Microbiome
Tumor microenvironment
TitleCross-talk between the microbiome and chronic inflammation in esophageal cancer: potential driver of oncogenesis
TypeArticle
Pagination281-299
Issue Number2
Volume Number41
ESSN1573-7233


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