Show simple item record

AuthorAbdelaziz, Nouha
AuthorTherachiyil, Lubna
AuthorSadida, Hana Q.
AuthorAli, Ateeque Mohamed
AuthorKhan, Omar S.
AuthorSingh, Mayank
AuthorKhan, Abdul Q.
AuthorAkil, Ammira S.Al Shabeeb
AuthorBhat, Ajaz A.
AuthorUddin, Shahab
Available date2023-11-15T07:56:46Z
Publication Date2023-01-01
Publication NameInternational Review of Cell and Molecular Biology
Identifierhttp://dx.doi.org/10.1016/bs.ircmb.2023.04.005
CitationAbdelaziz, N., Therachiyil, L., Sadida, H. Q., Ali, A. M., Khan, O. S., Singh, M., ... & Uddin, S. (2023). Epigenetic inhibitors and their role in cancer therapy. In International Review of Cell and Molecular Biology (Vol. 380, pp. 211-251). Academic Press.‏
ISBN9780443221781
ISSN19376448
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85169526387&origin=inward
URIhttp://hdl.handle.net/10576/49331
AbstractEpigenetic modifications to DNA are crucial for normal cellular and biological functioning. DNA methylation, histone modifications, and chromatin remodeling are the most common epigenetic mechanisms. These changes are heritable but still reversible. The aberrant epigenetic alterations, such as DNA methylation, histone modification, and non-coding RNA (ncRNA)-mediated gene regulation, play an essential role in developing various human diseases, including cancer. Recent studies show that synthetic and dietary epigenetic inhibitors attenuate the abnormal epigenetic modifications in cancer cells and therefore have strong potential for cancer treatment. In this chapter, we have highlighted various types of epigenetic modifications, their mechanism, and as drug targets for epigenetic therapy.
Languageen
PublisherElsevier
SubjectAcetylation
Cancer
Chromatin remodeling
Epigenetic modifications
HDAC inhibitors
Methylation
TitleEpigenetic inhibitors and their role in cancer therapy
TypeArticle
Pagination211-251
Volume Number380
dc.accessType Abstract Only


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record