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    Estrogens and the risk of breast cancer: A narrative review of literature

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    Estrogens and the risk of breast cancer A narrative review of literature.pdf (3.055Mb)
    Date
    2023-09-01
    Author
    Al-Shami, Khayry
    Awadi, Sajeda
    Khamees, Almu'atasim
    Alsheikh, Ahmad Malek
    Al-Sharif, Sumaiya
    Ala’ Bereshy, Raneem
    Al-Eitan, Sharaf F.
    Banikhaled, Sajedah H.
    Al-Qudimat, Ahmad R.
    Al-Zoubi, Raed M.
    Al Zoubi, Mazhar Salim
    ...show more authors ...show less authors
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    Abstract
    In female mammals, the development and regulation of the reproductive system and non-reproductive system are significantly influenced by estrogens (oestrogens). In addition, lipid metabolism is another physiological role of estrogens. Estrogens act through different types of receptors to introduce signals to the target cell by affecting many estrogen response elements. Breast cancer is considered mostly a hormone-dependent disease. Approximately 70% of breast cancers express progesterone receptors and/or estrogen receptors, and they are a good marker for cancer prognosis. This review will discuss estrogen metabolism and the interaction of estrogen metabolites with breast cancer. The carcinogenic role of estrogen is discussed in light of both conventional and atypical cancers susceptible to hormones, such as prostate, endometrial, and lung cancer, as we examine how estrogen contributes to the formation and activation of breast cancer. In addition, this review will discuss other factors that can be associated with estrogen-driven breast cancer.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85171832026&origin=inward
    DOI/handle
    http://dx.doi.org/10.1016/j.heliyon.2023.e20224
    http://hdl.handle.net/10576/49335
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    • Public Health [‎487‎ items ]

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