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AuthorShahzadi, Iram
AuthorIslam, Muhammad
AuthorSaeed, Hamid
AuthorHaider, Ali
AuthorShahzadi, Anum
AuthorRathore, Hassan Anwer
AuthorUl-Hamid, Anwar
AuthorAbd-Rabboh, Hisham S.M.
AuthorIkram, Muhammad
Available date2023-11-19T05:45:31Z
Publication Date2023
Publication NameInternational Journal of Biological Macromolecules
ResourceScopus
ISSN1418130
URIhttp://dx.doi.org/10.1016/j.ijbiomac.2023.126827
URIhttp://hdl.handle.net/10576/49406
AbstractCurcumin (diferuloylmethane), the primary curcuminoid in turmeric rhizome, has been acknowledged as a bioactive compound for numerous pharmacological activities. Nonetheless, the hydrophobic nature, rapid metabolism, and physicochemical and biological instability of this phenolic compound correspond to its poor bioavailability. So, recent scientific advances have found many components and strategies for enhancing the bioavailability of curcumin with the inclusion of biotechnology and nanotechnology to address its existing limitations. Therefore, In this study, copolymerized aqua-gel was synthesized by graft polymerization of poly-acrylic acid (P-AA) on cellulose nanocrystals (CNC), after that Curcuma longa (Cur) was incorporated as dopant (5, 10, 15, and 25 mg) in hydrogel (Cur/C-P) as a stabilizing agent for evaluation of bacterial potential and sewage treatment. The antioxidant tendency of 25 mg Cur/C-P was much higher (72.21 %) than other samples and displayed a catalytic activity of up to 93.89 % in acidic conditions and optimized bactericidal inclinations toward gram-positive bacterial strains. Furthermore, ligand binding was conducted against targeted protein enoyl-[acylcarrier-protein] reductase (FabI) enzyme to comprehend the putative mechanism of microbicidal action of CNC-PAA (C-P), Cur/C-P, and curcumin. Our outcomes suggest that 25 mg Cur/C-P hydrogels are plausible sources for hybrid, multifunctional biological activity.
SponsorThe authors thank the Higher education commission (HEC) Pakistan through NRPU-20-17615 and authors extend their appreciation to the Deanship of Scientific Research at King Khalid University , Saudi Arabia for funding this work through Small Groups Project under Grant Number ( RGP.2/228/44 ).
Languageen
PublisherElsevier
SubjectAcrylic acid (AA)
Aqua-gel
Curcuma longa
TitleSynthesis of curcuma longa doped cellulose grafted hydrogel for catalysis, bactericidial and insilico molecular docking analysis
TypeArticle
Volume Number253
dc.accessType Abstract Only


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