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المؤلفBhat, Ajaz A.
المؤلفNisar, Sabah
المؤلفSingh, Mayank
المؤلفAshraf, Bazella
المؤلفMasoodi, Tariq
المؤلفPrasad, Chandra P.
المؤلفSharma, Atul
المؤلفMaacha, Selma
المؤلفKaredath, Thasni
المؤلفHashem, Sheema
المؤلفYasin, Syed Besina
المؤلفBagga, Puneet
المؤلفReddy, Ravinder
المؤلفFrennaux, Michael P.
المؤلفUddin, Shahab
المؤلفDhawan, Punita
المؤلفHaris, Mohammad
المؤلفMacha, Muzafar A.
تاريخ الإتاحة2023-12-13T10:58:01Z
تاريخ النشر2022-08-01
اسم المنشورCancer Communications
المعرّفhttp://dx.doi.org/10.1002/cac2.12295
الاقتباسBhat, AA, Nisar, S, Singh, M, Ashraf, B, Masoodi, T, Prasad, CP, et al. Cytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy. Cancer Commun. 2022; 42: 689–715. https://doi.org/10.1002/cac2.12295
الرقم المعياري الدولي للكتاب2523-3548
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85133455385&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/50384
الملخصColorectal cancer (CRC) is a predominant life-threatening cancer, with liver and peritoneal metastases as the primary causes of death. Intestinal inflammation, a known CRC risk factor, nurtures a local inflammatory environment enriched with tumor cells, endothelial cells, immune cells, cancer-associated fibroblasts, immunosuppressive cells, and secretory growth factors. The complex interactions of aberrantly expressed cytokines, chemokines, growth factors, and matrix-remodeling enzymes promote CRC pathogenesis and evoke systemic responses that affect disease outcomes. Mounting evidence suggests that these cytokines and chemokines play a role in the progression of CRC through immunosuppression and modulation of the tumor microenvironment, which is partly achieved by the recruitment of immunosuppressive cells. These cells impart features such as cancer stem cell-like properties, drug resistance, invasion, and formation of the premetastatic niche in distant organs, promoting metastasis and aggressive CRC growth. A deeper understanding of the cytokine- and chemokine-mediated signaling networks that link tumor progression and metastasis will provide insights into the mechanistic details of disease aggressiveness and facilitate the development of novel therapeutics for CRC. Here, we summarized the current knowledge of cytokine- and chemokine-mediated crosstalk in the inflammatory tumor microenvironment, which drives immunosuppression, resistance to therapeutics, and metastasis during CRC progression. We also outlined the potential of this crosstalk as a novel therapeutic target for CRC. The major cytokine/chemokine pathways involved in cancer immunotherapy are also discussed in this review.
راعي المشروعOpen access publication is supported by Qatar National Library.
اللغةen
الناشرWiley
الموضوعchemokine
colorectal cancer
cytokine
drug resistance
epithelial-mesenchymal transition
immunosuppression
immunotherapy
inflammation
metastasis
tumor microenvironment
العنوانCytokine- and chemokine-induced inflammatory colorectal tumor microenvironment: Emerging avenue for targeted therapy
النوعArticle Review
الصفحات689-715
رقم العدد8
رقم المجلد42
ESSN2523-3548
dc.accessType Open Access


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