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المؤلفAbdulilah Dawoud, Bani-Yaseen
المؤلفAl-Zoubi, Raed M.
المؤلفShkoor, Mohanad
تاريخ الإتاحة2024-01-22T06:15:05Z
تاريخ النشر2023-11-30
اسم المنشورHeliyon
المعرّفhttp://dx.doi.org/10.1016/j.heliyon.2023.e20767
الاقتباسBani-Yaseen, A. D., Al-Zoubi, R. M., & Shkoor, M. (2023). Spectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac. Heliyon, 9(11).
الرقم المعياري الدولي للكتاب24058440
معرّف المصادر الموحدhttps://www.sciencedirect.com/science/article/pii/S2405844023079756
معرّف المصادر الموحدhttp://hdl.handle.net/10576/51013
الملخصThe solvent effects on the photochemical conversion rate of the photosensitizing drug diclofenac (DCF) were investigated using steady-state fluorescence spectroscopy. The spectral information obtained for the photochemical reaction of DCF in a set of neat solvents demonstrates that the photoconversion reaction rate of DCF is not only medium polarity dependent but also hydrogen-bonding dependent. The solvent effects were qualitatively and quantitatively assessed employing various solvatochromic models, including multi-parameter linear regression analysis (MLRA). Interestingly, the MLRA results (R = 0.99) revealed that the photoconversion rate increases with increasing solvent polarizability (π*) and H-bond donor capability (α), whereas the rate decreases with increasing hydrogen-bond acceptor capability (β). However, predominant effect of the solvent acidity compared to basicity and polarizability was observed. A hypothesis rationalizing the effects of H-bonding and medium polarity on DCF photoconversion reaction is presented and discussed.
راعي المشروعPartial support from Qatar University is acknowledged. Open Access funding provided by the Qatar National Library.
اللغةen
الناشرElsevier
الموضوعDiclofenac
Photoconversion
Fluorescence
Solvent effects
Solvatochromic models
العنوانSpectrofluorometric investigations on the solvent effects on the photocyclization reaction of diclofenac
النوعArticle
رقم العدد11
رقم المجلد9
Open Access user License http://creativecommons.org/licenses/by/4.0/
dc.accessType Open Access


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