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AuthorS., Sri Hari
AuthorG., Keerthana
AuthorDey, Hrituraj
AuthorSangoji, Rahul V.
AuthorThirumal Kumar, D.
AuthorZayed, Hatem
AuthorVasudevan, Karthick
AuthorGeorge Priya Doss, C.
Available date2024-01-28T11:03:15Z
Publication Date2023-01
Publication NameAdvances in Protein Chemistry and Structural Biology
Identifierhttp://dx.doi.org/10.1016/bs.apcsb.2023.02.011
CitationSH, S., Dey, H., Sangoji, R. V., Zayed, H., & Vasudevan, K. (2023). Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis. Advances in Protein Chemistry and Structural Biology, 137, 181-203.
ISSN1876-1623
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85152641311&origin=inward
URIhttp://hdl.handle.net/10576/51251
AbstractColorectal cancer (CRC) is third cancer causing death in the world. CRC is associated with disrupting the circadian rhythm (CR), closely associating the CRC progression and the dysregulation of genes involved in the biological clock. In this study, we aimed to understand the circadian rhythm changes in patients diagnosed with CRC. We used the GEO database with the ID GSE46549 for our analysis, which consists of 32 patients with CRC and one as normal control. Our study has identified five essential genes involved in CRC, HAPLN1, CDH12, IGFBP5, DCHS2, and DOK5, and had different enriched pathways, such as the Wnt-signaling pathway, at different time points of study. As a part of our study, we also identified various related circadian genes, such as CXCL12, C1QTNF2, MRC2, and GLUL, from the Circadian Gene Expression database, that played a role in circadian rhythm and CRC development. As circadian timing can influence the host tissue's ability to tolerate anticancer medications, the genes reported can serve as a potential drug target for treating CRC and become beneficial to translational settings.
Languageen
PublisherElsevier
SubjectBiological clock
Circadian rhythm
Colorectal cancer
HAPLN1
Wnt pathway
TitleIdentification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis
TypeBook chapter
Pagination181-203
Volume Number137
ESSN1876-1631
dc.accessType Abstract Only


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