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AuthorBassi, Marta
AuthorBilel, Sabrine
AuthorTirri, Micaela
AuthorCorli, Giorgia
AuthorDi Rosa, Fabiana
AuthorGregori, Adolfo
AuthorAlkilany, Alaaldin M.
AuthorRachid, Ousama
AuthorRoda, Elisa
AuthorZauli, Giorgio
AuthorLocatelli, Carlo Alessandro
AuthorMarti, Matteo
Available date2024-02-25T09:18:48Z
Publication Date2024-01-12
Publication NamePsychopharmacology
Identifierhttp://dx.doi.org/10.1007/s00213-024-06526-8
CitationBassi, M., Bilel, S., Tirri, M., Corli, G., Di Rosa, F., Gregori, A., ... & Marti, M. (2024). Pharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence. Psychopharmacology, 1-23.
ISSN0033-3158
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85182205448&origin=inward
URIhttp://hdl.handle.net/10576/52180
AbstractRationale: The 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT, known online as “Moxy”) is a new psychedelic tryptamine first identified on Italian national territory in 2014. Its hallucinogen effects are broadly well-known; however, only few information is available regarding its pharmaco-toxicological effects. Objectives: Following the seizure of this new psychoactive substances by the Arm of Carabinieri and the occurrence of a human intoxication case, in the current study we had the aim to characterize the in vivo acute effects of systemic administration of 5-MeO-MiPT (0.01–30 mg/kg i.p.) on sensorimotor (visual, acoustic, and overall tactile) responses, thermoregulation, and stimulated motor activity (drag and accelerod test) in CD-1 male mice. We also evaluated variation on sensory gating (PPI, prepulse inhibition; 0.01–10 mg/kg i.p.) and on cardiorespiratory parameters (MouseOx and BP-2000; 30 mg/kg i.p.). Lastly, we investigated the in silico ADMET (absorption, distribution, metabolism, excretion, toxicity) profile of 5-MeO-MiPT compared to 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) and N,N-dimethyltryptamine (DMT). Results: This study demonstrates that 5-MeO-MiPT dose-dependently inhibits sensorimotor and PPI responses and, at high doses, induces impairment of the stimulated motor activity and cardiorespiratory changes in mice. In silico prediction shows that the 5-MeO-MiPT toxicokinetic profile shares similarities with 5-MeO-DIPT and DMT and highlights a cytochrome risk associated with this compound. Conclusions: Consumption of 5-MeO-MiPT can affect the ability to perform activities and pose a risk to human health status, as the correspondence between the effects induced in mice and the symptoms occurred in the intoxication case suggests. However, our findings suggest that 5-MeO-MiPT should not be excluded from research in the psychiatric therapy field.
Languageen
PublisherSpringer Nature
Subject5-MeO-MiPT
ADMET prediction
Behaviour
Cardiorespiratory changes
Human intoxication
Prepulse inhibition
Serotoninergic hallucinogens
TitlePharmaco-toxicological effects of the novel tryptamine hallucinogen 5-MeO-MiPT on motor, sensorimotor, physiological, and cardiorespiratory parameters in mice—from a human poisoning case to the preclinical evidence
TypeArticle
Pagination1-23
ESSN1432-2072
dc.accessType Open Access


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