Plastic Membrane Electrodes for the Potentiometric Determination of Codeine in Pharmaceutical Preparations
الملخص
Four PVC membrane electrode systems responsive to codeinium cation are described. These electrodes are based on the use of the ion-association complexes of the codeinium cation with tetraphenylborate and reineckate counter-anions as ion-exchange sites in a PVC matrix plasticized with dioctylphthalate and dibutylsebacate. The performance characteristics of these electrodes reveal fast, stable and near-Nernstian responses for codeine down to concentrations of 3.5–7.0 × 10−5 M. Over the pH range 2.5–7, the electrodes are satisfactory for manual and flow injection determination of codeine in various pharmaceutical preparations. There is negligible interference from a number of inorganic and organic cations and some common drug excipients. In the direct determination of 30 μg/ml -1.0 mg/ml codeine, the average recovery is 100.6% and the mean standard deviation is ± 0.8%. The results compare favorably with those obtained by the British Pharmacopoeia method.
المجموعات
- الكيمياء وعلوم الأرض [557 items ]