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AuthorKuttikrishnan, Shilpa
AuthorHasan, Maram
AuthorPrabhu, Kirti S.
AuthorEl-Elimat, Tamam
AuthorOberlies, Nicholas H.
AuthorPearce, Cedric J.
AuthorAlali, Feras Q.
AuthorAhmad, Aamir
AuthorPourkarimi, Ehsan
AuthorBhat, Ajaz A.
AuthorYalcin, Huseyin C.
AuthorUddin, Shahab
Available date2024-03-13T12:26:57Z
Publication Date2024-02-01
Publication NameExperimental Cell Research
Identifierhttp://dx.doi.org/10.1016/j.yexcr.2023.113907
CitationKuttikrishnan, S., Hasan, M., Prabhu, K. S., El-Elimat, T., Oberlies, N. H., Pearce, C. J., ... & Uddin, S. (2024). Exploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model. Experimental Cell Research, 435(1), 113907.‏
ISSN00144827
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85181804217&origin=inward
URIhttp://hdl.handle.net/10576/53031
AbstractNeosetophomone B (NSP–B) is a unique meroterpenoid fungal secondary metabolite that has previously demonstrated promising anti-cancer properties against various cancer cell lines in vitro. However, its in vivo anti-cancer potential remaines unexplored. To fill this gap in our knowledge, we tested NSP-B's in vivo anti-cancer activity using a zebrafish model, an organism that has gained significant traction in biomedical research due to its genetic similarities with humans and its transparent nature, allowing real-time tumor growth observation. For our experiments, we employed the K562-injected zebrafish xenograft model. Upon treating these zebrafish with NSP-B, we observed a marked reduction in the size and number of tumor xenografts. Delving deeper, our analyses indicated that NSP-B curtailed tumor growth and proliferation of leukemic grafted xenograft within the zebrafish. These results show that NSP-B possesses potent in vivo anti-cancer properties, making it a potential novel therapeutic agent for addressing hematological malignancies.
Languageen
PublisherElsevier Inc.
SubjectCell proliferation
Fungal secondary metabolites
Leukemia
Neosetophomone B
Xenograft model
Zebrafish
TitleExploring the in vivo anti-cancer potential of Neosetophomone B in leukemic cells using a zebrafish xenograft model
TypeArticle
Issue Number1
Volume Number435
dc.accessType Abstract Only


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